Manufacture of Pharmaceutical Co-Crystals Using Twin Screw Extrusion: A Solvent-Less and Scalable Process

被引：101

作者：

Medina, Cesar ^{[1
]}

Daurio, Dominick ^{[1
]}

Nagapudi, Karthik ^{[1
]}

Alvarez-Nunez, Fernando ^{[1
]}

机构：

[1] Amgen Inc, Small Mol Proc & Prod Dev, Thousand Oaks, CA 91320 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2010年 / 99卷 / 04期

关键词：

MOLECULAR-COMPLEXES; PHASE-DIAGRAMS; COCRYSTALS; ACID; SOLUBILITY; DRUG;

D O I：

10.1002/jps.21942

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：1693 / 1696

页数：4

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