The role of lactate in sepsis and COVID-19: Perspective from contracting skeletal muscle metabolism

被引：37

作者：

Iepsen, Ulrik Winning ^{[1
,2
]}

Plovsing, Ronni R. ^{[3
,4
]}

Tjelle, Klaus ^{[3
]}

Foss, Nicolai Bang ^{[3
,4
]}

Meyhoff, Christian S. ^{[2
,4
]}

Ryrso, Camilla K. ^{[1
]}

Berg, Ronan M. G. ^{[1
,5
,6
,7
]}

Secher, Niels H. ^{[4
,8
]}

机构：

[1] Copenhagen Univ Hosp, Ctr Phys Act Res, Rigshosp, Blegdamsvej 9, DK-7641 Copenhagen, Denmark

[2] Copenhagen Univ Hosp, Dept Anaesthesia & Intens Care, Bispebjerg & Frederiksberg Hosp, Copenhagen, Denmark

[3] Copenhagen Univ Hosp, Dept Anaesthesiol, Hvidovre Hosp, Copenhagen, Denmark

[4] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

[5] Univ Copenhagen, Fac Hlth & Med Sci, Dept Biomed Sci, Copenhagen, Denmark

[6] Copenhagen Univ Hosp, Dept Clin Physiol Nucl Med & PET, Rigshosp, Copenhagen, Denmark

[7] Univ South Wales, Fac Life Sci & Educ, Neurovasc Res Lab, Pontypridd, M Glam, Wales

[8] Copenhagen Univ Hosp, Dept Anaesthesiol, Rigshosp, Copenhagen, Denmark

来源：

EXPERIMENTAL PHYSIOLOGY | 2022年 / 107卷 / 07期

关键词：

acute respiratory distress syndrome; cardiovascular system; critical care; exercise; lung injury; BLOOD-FLOW; EXERCISE; DEHYDROGENASE; HUMANS; WORK; PHYSIOLOGY; OXIDATION; SEVERITY; INJURY;

D O I：

10.1113/EP089474

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

New Findings What is the topic of this review? Lactate is considered an important substrate for mitochondria in the muscles, heart and brain during exercise and is the main gluconeogenetic precursor in the liver and kidneys. In this light, we review the (patho)physiology of lactate metabolism in sepsis and coronavirus disease 2019 (COVID-19).

引用

页码：665 / 673

页数：9

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