The role of lactate in sepsis and COVID-19: Perspective from contracting skeletal muscle metabolism

被引：37
作者：
Iepsen, Ulrik Winning [1 ,2 ]
Plovsing, Ronni R. [3 ,4 ]
Tjelle, Klaus [3 ]
Foss, Nicolai Bang [3 ,4 ]
Meyhoff, Christian S. [2 ,4 ]
Ryrso, Camilla K. [1 ]
Berg, Ronan M. G. [1 ,5 ,6 ,7 ]
Secher, Niels H. [4 ,8 ]
机构：
[1] Copenhagen Univ Hosp, Ctr Phys Act Res, Rigshosp, Blegdamsvej 9, DK-7641 Copenhagen, Denmark
[2] Copenhagen Univ Hosp, Dept Anaesthesia & Intens Care, Bispebjerg & Frederiksberg Hosp, Copenhagen, Denmark
[3] Copenhagen Univ Hosp, Dept Anaesthesiol, Hvidovre Hosp, Copenhagen, Denmark
[4] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
[5] Univ Copenhagen, Fac Hlth & Med Sci, Dept Biomed Sci, Copenhagen, Denmark
[6] Copenhagen Univ Hosp, Dept Clin Physiol Nucl Med & PET, Rigshosp, Copenhagen, Denmark
[7] Univ South Wales, Fac Life Sci & Educ, Neurovasc Res Lab, Pontypridd, M Glam, Wales
[8] Copenhagen Univ Hosp, Dept Anaesthesiol, Rigshosp, Copenhagen, Denmark
来源：
EXPERIMENTAL PHYSIOLOGY | 2022年 / 107卷 / 07期
关键词：
acute respiratory distress syndrome; cardiovascular system; critical care; exercise; lung injury; BLOOD-FLOW; EXERCISE; DEHYDROGENASE; HUMANS; WORK; PHYSIOLOGY; OXIDATION; SEVERITY; INJURY;
D O I：
10.1113/EP089474
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
New Findings What is the topic of this review? Lactate is considered an important substrate for mitochondria in the muscles, heart and brain during exercise and is the main gluconeogenetic precursor in the liver and kidneys. In this light, we review the (patho)physiology of lactate metabolism in sepsis and coronavirus disease 2019 (COVID-19).
引用
收藏
页码：665 / 673
页数：9
相关论文
共 53 条
[1]   Scientific contributions of A. V. Hill: Exercise physiology pioneer [J].
Bassett, DR .
JOURNAL OF APPLIED PHYSIOLOGY, 2002, 93 (05) :1567-1582
[2]   Sympathetic Vasoconstrictor Responsiveness of the Leg Vasculature During Experimental Endotoxemia and Hypoxia in Humans [J].
Brassard, Patrice ;
Zaar, Morten ;
Thaning, Pia ;
Secher, Niels H. ;
Rosenmeier, Jaya B. .
CRITICAL CARE MEDICINE, 2016, 44 (04) :755-763
[3]   Association between mitochondrial dysfunction and severity and outcome of septic shock [J].
Brealey, D ;
Brand, M ;
Hargreaves, I ;
Heales, S ;
Land, J ;
Smolenski, R ;
Davies, NA ;
Cooper, CE ;
Singer, M .
LANCET, 2002, 360 (9328) :219-223
[4]   Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle [J].
Brooks, GA ;
Dubouchaud, H ;
Brown, M ;
Sicurello, JP ;
Butz, CE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (03) :1129-1134
[5]   The Science and Translation of Lactate Shuttle Theory [J].
Brooks, George A. .
CELL METABOLISM, 2018, 27 (04) :757-785
[6]   Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. [J].
Brower, RG ;
Matthay, MA ;
Morris, A ;
Schoenfeld, D ;
Thompson, BT ;
Wheeler, A ;
Wiedemann, HP ;
Arroliga, AC ;
Fisher, CJ ;
Komara, JJ ;
Perez-Trepichio, P ;
Parsons, PE ;
Wolkin, R ;
Welsh, C ;
Fulkerson, WJ ;
MacIntyre, N ;
Mallatratt, L ;
Sebastian, M ;
McConnell, R ;
Wilcox, C ;
Govert, J ;
Thompson, D ;
Clemmer, T ;
Davis, R ;
Orme, J ;
Weaver, L ;
Grissom, C ;
Eskelson, M ;
Young, M ;
Gooder, V ;
McBride, K ;
Lawton, C ;
d'Hulst, J ;
Peerless, JR ;
Smith, C ;
Brownlee, J ;
Pluss, W ;
Kallet, R ;
Luce, JM ;
Gottlieb, J ;
Elmer, M ;
Girod, A ;
Park, P ;
Daniel, B ;
Gropper, M ;
Abraham, E ;
Piedalue, F ;
Glodowski, J ;
Lockrem, J ;
McIntyre, R .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (18) :1301-1308
[7]   Endotoxemia stimulates skeletal muscle Na+-K+-ATPase and raises blood lactate under aerobic conditions in humans [J].
Bundgaard, H ;
Kjeldsen, K ;
Krabbe, KS ;
Van Hall, G ;
Simonsen, L ;
Qvist, J ;
Hansen, CM ;
Moller, K ;
Fonsmark, L ;
Madsen, PL ;
Pedersen, BK .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2003, 284 (03) :H1028-H1034
[8]   Lactate Measurements in Sepsis-Induced Tissue Hypoperfusion: Results From the Surviving Sepsis Campaign Database [J].
Casserly, Brian ;
Phillips, Gary S. ;
Schorr, Christa ;
Dellinger, R. Phillip ;
Townsend, Sean R. ;
Osborn, Tiffany M. ;
Reinhart, Konrad ;
Selvakumar, Narendran ;
Levy, Mitchell M. .
CRITICAL CARE MEDICINE, 2015, 43 (03) :567-573
[9]   Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial [J].
Castro, Ricardo ;
Kattan, Eduardo ;
Ferri, Giorgio ;
Pairumani, Ronald ;
Daniel Valenzuela, Emilio ;
Alegria, Leyla ;
Oviedo, Vanessa ;
Pavez, Nicolas ;
Soto, Dagoberto ;
Vera, Magdalena ;
Santis, Cesar ;
Astudillo, Brusela ;
Cid, Maria Alicia ;
Bravo, Sebastian ;
Ospina-Tascon, Gustavo ;
Bakker, Jan ;
Hernandez, Glenn .
ANNALS OF INTENSIVE CARE, 2020, 10 (01)
[10]  
Castro Victor M, 2020, medRxiv, DOI 10.1101/2020.05.04.20090555
123456