Impact of Direct-Acting Antivirals on the Burden of HCV Infection Among Persons Who Inject Drugs and Men Who Have Sex With Men in the Swiss HIV Cohort Study

被引：17

作者：

Salazar-Vizcaya, Luisa ^{[1
]}

Wandeler, Gilles ^{[1
,9
,10
]}

Fehr, Jan ^{[2
]}

Braun, Dominique ^{[2
,3
,4
]}

Cavassini, Matthias ^{[3
,4
]}

Stoeckle, Marcel ^{[5
]}

Bernasconi, Enos ^{[6
]}

Hoffmann, Matthias ^{[7
]}

Rougemont, Mathieu ^{[8
]}

Beguelin, Charles ^{[1
]}

Rauch, Andri ^{[1
]}

机构：

[1] Univ Bern, Bern Univ Hosp, Dept Infect Dis, Bern, Switzerland

[2] Univ Hosp Zurich, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland

[3] Univ Zurich, Inst Med Virol, Zurich, Switzerland

[4] Univ Lausanne, Univ Hosp Lausanne, Div Infect Dis, Lausanne, Switzerland

[5] Univ Hosp Basel, Dept Infect Dis & Hosp Hyg, Basel, Switzerland

[6] Reg Hosp Lugano, Div Infect Dis, Lugano, Switzerland

[7] Cantonal Hosp St Gallen, Div Infect Dis & Hosp Epidemiol, St Gallen, Switzerland

[8] Univ Geneva, Univ Hosp Geneva, Div Infect Dis, Geneva, Switzerland

[9] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland

[10] Univ Zurich, Epidemiol Biostat & Prevent Inst, Dept Publ Hlth, Zurich, Switzerland

来源：

OPEN FORUM INFECTIOUS DISEASES | 2018年 / 5卷 / 07期

基金：

瑞士国家科学基金会;

关键词：

DAA; HCV; viral replication; PWID; MSM; HEPATITIS-C VIRUS; POSITIVE MEN; TRANSMISSION; REINFECTION; COINFECTION; SURVIVAL; PEOPLE;

D O I：

10.1093/ofid/ofy154

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the Swiss HIV Cohort Study, the number of people who inject drugs with replicating hepatitis C virus (HCV) infection decreased substantially after the introduction of direct-acting antivirals (DAAs). Among men who have sex with men, the increase in DAA uptake and efficacy was counterbalanced by frequent incident HCV infections.

引用

页数：4

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