Pyridazine derivatives.: Part 33:: Sonogashira approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones

被引：56

作者：

Coelho, A ^{[1
]}

Sotelo, E ^{[1
]}

Raviña, E ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Fac Farm, Dept Quim Organ, Lab Quim Farmaceut, Santiago De Compostela 15782, Spain

来源：

TETRAHEDRON | 2003年 / 59卷 / 14期

关键词：

pyridazinones; Sonogashira coupling; chalcone;

D O I：

10.1016/S0040-4020(03)00263-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several 6-phenyl-3(2H)-pyridazinones bearing different alkynyl groups at position 5 have been prepared by a palladium-catalysed Sonogashira cross-coupling reaction. An interesting base-promoted electronically permitted isomerization has been observed during the coupling of 1-phenyl-2-propyn-1-ol. This rearrangement afforded the E-chalcone 6 in excellent yield. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2477 / 2484

页数：8

共 39 条

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