Omicron infection enhances Delta antibody immunity in vaccinated persons

被引：60

作者：

Khan, Khadija ^{[1
,2
]}

Karim, Farina ^{[1
,2
]}

Cele, Sandile ^{[1
,2
]}

Reedoy, Kajal ^{[1
]}

San, James Emmanuel ^{[3
]}

Lustig, Gila ^{[4
]}

Tegally, Houriiyah ^{[3
,5
]}

Rosenberg, Yuval ^{[6
]}

Bernstein, Mallory ^{[1
]}

Jule, Zesuliwe ^{[1
]}

Ganga, Yashica ^{[1
]}

Ngcobo, Nokuthula ^{[1
]}

Mazibuko, Matilda ^{[1
]}

Mthabela, Ntombifuthi ^{[1
]}

Mhlane, Zoey ^{[1
]}

Mbatha, Nikiwe ^{[1
]}

Miya, Yoliswa ^{[1
]}

Giandhari, Jennifer ^{[3
]}

Ramphal, Yajna ^{[3
]}

Naidoo, Taryn ^{[1
]}

Sivro, Aida ^{[4
,7
]}

Samsunder, Natasha ^{[4
]}

Kharsany, Ayesha B. M. ^{[4
]}

Amoako, Daniel ^{[8
]}

Bhiman, Jinal N. ^{[8
]}

Manickchund, Nithendra ^{[9
]}

Karim, Quarraisha Abdool ^{[4
,10
]}

Magula, Nombulelo ^{[11
]}

Karim, Salim S. Abdool ^{[4
,10
]}

Gray, Glenda ^{[12
]}

Hanekom, Willem ^{[1
,13
]}

von Gottberg, Anne ^{[8
,14
]}

Team, COMMIT-KZN

Milo, Ron ^{[6
]}

Gosnell, Bernadett, I ^{[9
]}

Lessells, Richard J. ^{[3
,4
]}

Moore, Penny L. ^{[4
,8
,15
,16
]}

de Oliveira, Tulio ^{[3
,4
,5
,17
]}

Moosa, Mahomed-Yunus S. ^{[9
]}

Sigal, Alex ^{[1
,2
,4
,18
]}

机构：

[1] Africa Hlth Res Inst, Durban, South Africa

[2] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Durban, South Africa

[3] KwaZulu Natal Res Innovat & Sequencing Platform, Durban, South Africa

[4] Ctr AIDS Programme Res South Africa, Durban, South Africa

[5] Stellenbosch Univ, Ctr Epidem Response & Innovat, Sch Data Sci & Computat Thinking, Stellenbosch, South Africa

[6] Weizmann Inst Sci, Dept Plant & Environm Sci, Rehovot, Israel

[7] Univ KwaZulu Natal, Dept Med Microbiol, Durban, South Africa

[8] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Johannesburg, South Africa

[9] Univ KwaZulu Natal, Nelson R Mandela Sch Clin Med, Dept Infect Dis, Durban, South Africa

[10] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA

[11] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Dept Internal Med, Durban, South Africa

[12] South African Med Res Council, Cape Town, South Africa

[13] UCL, Div Infect & Immun, London, England

[14] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa

[15] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, SAMRC Antibody Immun Res Unit, Johannesburg, South Africa

[16] Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa

[17] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[18] Max Planck Inst Infect Biol, Berlin, Germany

来源：

NATURE | 2022年 / 607卷 / 7918期

基金：

英国医学研究理事会; 美国国家卫生研究院; 英国惠康基金;

关键词：

SARS-COV-2; OMICRON;

D O I：

10.1038/s41586-022-04830-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The extent to which Omicron infection(1-9), with or without previous vaccination, elicits protection against the previously dominant Delta (B.1.617.2) variant is unclear. Here we measured the neutralization capacity against variants of severe acute respiratory syndrome coronavirus 2 in 39 individuals in South Africa infected with the Omicron sublineage BA.1 starting at a median of 6 (interquartile range 3-9) days post symptom onset and continuing until last follow-up sample available, a median of 23 (interquartile range 19-27) days post symptoms to allow BA.1-elicited neutralizing immunity time to develop. Fifteen participants were vaccinated with Pfizer's BNT162b2 or Johnson & Johnson's Ad26.CoV2.S and had BA.1 breakthrough infections, and 24 were unvaccinated. BA.1 neutralization increased from a geometric mean 50% focus reduction neutralization test titre of 42 at enrolment to 575 at the last follow-up time point (13.6-fold) in vaccinated participants and from 46 to 272 (6.0-fold) in unvaccinated participants. Delta virus neutralization also increased, from 192 to 1,091 (5.7-fold) in vaccinated participants and from 28 to 91 (3.0-fold) in unvaccinated participants. At the last time point, unvaccinated individuals infected with BA.1 had low absolute levels of neutralization for the non-BA.1 viruses and 2.2-fold lower BA.1 neutralization, 12.0-fold lower Delta neutralization, 9.6-fold lower Beta variant neutralization, 17.9-fold lower ancestral virus neutralization and 4.8-fold lower Omicron sublineage BA.2 neutralization relative to vaccinated individuals infected with BA.1. These results indicate that hybrid immunity formed by vaccination and Omicron BA.1 infection should be protective against Delta and other variants. By contrast, infection with Omicron BA.1 alone offers limited cross-protection despite moderate enhancement.

引用

页码：356 / +

页数：14

共 28 条

[1]

Andrews N, 2022, NEW ENGL J MED, V386, P1532, DOI [10.1016/S1473-3099(22)00309-7, 10.1056/NEJMoa2119451]

[2] Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies [J].

Cao, Yunlong ;

Wang, Jing ;

Jian, Fanchong ;

Xiao, Tianhe ;

Song, Weiliang ;

Yisimayi, Ayijiang ;

Huang, Weijin ;

Li, Qianqian ;

Wang, Peng ;

An, Ran ;

Wang, Yao ;

Niu, Xiao ;

Yang, Sijie ;

Liang, Hui ;

Sun, Haiyan ;

Li, Tao ;

Yu, Yuanling ;

Cui, Qianqian ;

Liu, Shuo ;

Yang, Xiaodong ;

Du, Shuo ;

Zhang, Zhiying ;

Hao, Xiaohua ;

Shao, Fei ;

Jin, Ronghua ;

Wang, Xiangxi ;

Xiao, Junyu ;

Wang, Youchun ;

Xie, Xiaoliang Sunney .

NATURE, 2022, 602 (7898) :657-+

[3]

Cele S., NATURE, DOI [10.1038/s41586-021-04387-1(2021), DOI 10.1038/S41586-021-04387-1(2021)]

[4] SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape [J].

Cele, Sandile ;

Karim, Farina ;

Lustig, Gila ;

San, James Emmanuel ;

Hermanus, Tandile ;

Tegally, Houriiyah ;

Snyman, Jumari ;

Moyo-Gwete, Thandeka ;

Wilkinson, Eduan ;

Bernstein, Mallory ;

Khan, Khadija ;

Hwa, Shi-Hsia ;

Tilles, Sasha W. ;

Singh, Lavanya ;

Giandhari, Jennifer ;

Mthabela, Ntombifuthi ;

Mazibuko, Matilda ;

Ganga, Yashica ;

Gosnell, Bernadett, I ;

Karim, Salim S. Abdool ;

Hanekom, Willem ;

Van Voorhis, Wesley C. ;

Ndung'u, Thumbi ;

Lessells, Richard J. ;

Moore, Penny L. ;

Moosa, Mahomed-Yunus S. ;

de Oliveira, Tulio ;

Sigal, Alex .

CELL HOST & MICROBE, 2022, 30 (02) :154-+

[5] Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma [J].

Cele, Sandile ;

Gazy, Inbal ;

Jackson, Laurelle ;

Hwa, Shi-Hsia ;

Tegally, Houriiyah ;

Lustig, Gila ;

Giandhari, Jennifer ;

Pillay, Sureshnee ;

Wilkinson, Eduan ;

Naidoo, Yeshnee ;

Karim, Farina ;

Ganga, Yashica ;

Khan, Khadija ;

Bernstein, Mallory ;

Balazs, Alejandro B. ;

Gosnell, Bernadett, I ;

Hanekom, Willem ;

Moosa, Mahomed-Yunus S. ;

Lessells, Richard J. ;

de Oliveira, Tulio ;

Sigal, Alex .

NATURE, 2021, 593 (7857) :142-+

[6]

Chemaitelly H., PREPRINT, DOI [10.1101/2022.02.24.22271440(2022, DOI 10.1101/2022.02.24.22271440(2022]

[7]

Davies M.-A., TROP MED INT HEALTH, DOI DOI 10.1111/TMI.13752(2022

[8] SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses [J].

Dejnirattisai, Wanwisa ;

Huo, Jiandong ;

Zhou, Daming ;

Zahradnik, Jiri ;

Supasa, Piyada ;

Liu, Chang ;

Duyvesteyn, Helen M. E. ;

Ginn, Helen M. ;

Mentzer, Alexander J. ;

Tuekprakhon, Aekkachai ;

Nutalai, Rungtiwa ;

Wang, Beibei ;

Dijokaite, Aiste ;

Khan, Suman ;

Avinoam, Ori ;

Bahar, Mohammad ;

Skelly, Donal ;

Adele, Sandra ;

Johnson, Sile Ann ;

Amini, Ali ;

Ritter, Thomas G. ;

Mason, Chris ;

Dold, Christina ;

Pan, Daniel ;

Assadi, Sara ;

Bellass, Adam ;

Omo-Dare, Nicola ;

Koeckerling, David ;

Flaxman, Amy ;

Jenkin, Daniel ;

Aley, Parvinder K. ;

Voysey, Merryn ;

Clemens, Sue Ann Costa ;

Naveca, Felipe Gomes ;

Nascimento, Valdinete ;

Nascimento, Fernanda ;

da Costa, Cristiano Fernandes ;

Resende, Paola Cristina ;

Pauvolid-Correa, Alex ;

Siqueira, Marilda M. ;

Baillie, Vicky ;

Serafin, Natali ;

Kwatra, Gaurav ;

Da Silva, Kelly ;

Madhi, Shabir A. ;

Nunes, Marta C. ;

Malik, Tariq ;

Openshaw, Peter J. M. ;

Baillie, J. Kenneth ;

Semple, Malcolm G. .

CELL, 2022, 185 (03) :467-+

[9] Reduced neutralisation of SARS-CoV-2 omicron B.1.1.529 variant by post-immunisation serum [J].

Dejnirattisai, Wanwisa ;

Shaw, Robert H. ;

Supasa, Piyada ;

Liu, Chang ;

Stuart, Arabella S. V. ;

Pollard, Andrew J. ;

Liu, Xinxue ;

Lambe, Teresa ;

Crook, Derrick ;

Stuart, Dave I. ;

Mongkolsapaya, Juthathip ;

Nguyen-Van-Tam, Jonathan S. ;

Snape, Matthew D. ;

Screaton, Gavin R. .

LANCET, 2022, 399 (10321) :234-236

[10]

Garcia-Beltran WF, 2022, CELL, V185, P457, DOI [10.1016/j.cell.2021.12.033, 10.1101/2021.12.14.21267755]

← 1 2 3 →