A new sesquiterpene from hairy root culture of Artemisia annua

被引：12

作者：

Zhai, Dan Dan ^{[3
]}

Jin, Hui Zi ^{[2
]}

Zhong, Jian Jiang ^{[1
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Minist Educ, Key Lab Microbial Metab, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[3] E China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 05期

关键词：

Artemisia annua; Sesquiterpene; Cytotoxicity; DRUG;

D O I：

10.1016/j.cclet.2010.01.034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new sesquiterpene (Z)-7-acetoxy-methyl-11-methyl-3-methylenedodeca-1,6,10-triene (AMDT) was isolated and identified from the methanol extract of the hairy root culture of Artemisia annua. The structure of AMDT was determined based on the analysis of spectroscopic data, notably of the 2D NMR spectra This new compound showed cytotoxicity against human tumor cell lines 95-D and HeLa with IC(50) values of 27 08 and 20.12 mu mol/L, respectively. (C) 2010 Jian Jiang Zhong Published by Elsevier B V on behalf of Chinese Chemical Society All rights reserved

引用

页码：590 / 592

页数：3

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