Antifungal drugs during pregnancy: an updated review

被引：90

作者：

Pilmis, Benoit ^{[1
]}

Jullien, Vincent ^{[2
]}

Sobel, Jack ^{[3
]}

Lecuit, Marc ^{[1
]}

Lortholary, Olivier ^{[1
]}

Charlier, Caroline ^{[1
]}

机构：

[1] Univ Paris 05, Sorbonne Paris Cite, Hop Necker Enfants Malad, Infect Dis Dept,Ctr Infectiol Necker Pasteur, Paris, France

[2] Univ Paris 05, Dept Pharmacol, Hop Europeen Georges Pompidou, Sorbonne Paris Cite,Inserm,U1229, Paris, France

[3] Wayne State Univ, Detroit, MI USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2015年 / 70卷 / 01期

关键词：

fetus; placenta; antifungal therapy; fungal infections; CLINICAL-PRACTICE GUIDELINES; INFECTIOUS-DISEASES-SOCIETY; VISCERAL LEISHMANIASIS; AMPHOTERICIN-B; DISSEMINATED BLASTOMYCOSIS; CONGENITAL-MALFORMATIONS; PROSPECTIVE COHORT; ORAL FLUCONAZOLE; BIRTH-DEFECTS; CASE SERIES;

D O I：

10.1093/jac/dku355

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Antifungal prescription remains a challenge in pregnant women because of uncertainties regarding fetal toxicity and altered maternal pharmacokinetic parameters that may affect efficacy or increase maternal and fetal toxicity. We present updated data reviewing the available knowledge and current recommendations regarding antifungal prescription in pregnancy. Amphotericin B remains the first-choice parenteral drug in spite of its well-established toxicity. Topical drugs are used throughout pregnancy because of limited absorption. Recent data have clarified the teratogenic effect of high-dose fluconazole during the first trimester and provided reassuring cumulative data regarding its use at a single low dose in this key period. Recent data have also provided additional safety data on itraconazole and lipidic derivatives of amphotericin B. Regarding newer antifungal drugs, including posaconazole and echinocandins, clinical data are critically needed before considering prescription in pregnancy.

引用

页码：14 / 22

页数：9

共 80 条

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