An efficient synthesis of aziridines from ephedrines

被引:5
作者
Cruz, Alejandro [1 ]
Irene Padilla-Martinez, Itzia [1 ]
Garcia-Baez, Efren V. [1 ]
机构
[1] IPN, Dept Ciencias Basicas, Unidad Profes Interdisciplinaria Biotecnol, Mexico City 07340, DF, Mexico
关键词
ASYMMETRIC TRANSFER HYDROGENATION; ONE-POT SYNTHESIS; CHIRAL AUXILIARY; ENANTIOSELECTIVE ADDITION; DIETHYLZINC; LIGANDS; ALCOHOLS; (S; S)-(+)-PSEUDOEPHEDRINE; PSEUDOEPHEDRINE; ALDEHYDES;
D O I
10.1016/j.tetasy.2010.05.007
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The reaction of chlorodeoxyephedrine hydrochlorides with one, two, and three molar equivalents of base was studied. Isochlorodeoxypseudoepherines were identified and assigned by H-1 and C-13 NMR data as intermediate compounds in the formation of cis-aziridines. Erythro and threo ephedrinethylethers were isolated as new compounds and analyzed by spectroscopic data. In addition, the erythro isomer was studied by X-ray diffraction. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:909 / 913
页数:5
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