An efficient synthesis of aziridines from ephedrines

被引：5

作者：

Cruz, Alejandro ^{[1
]}

Irene Padilla-Martinez, Itzia ^{[1
]}

Garcia-Baez, Efren V. ^{[1
]}

机构：

[1] IPN, Dept Ciencias Basicas, Unidad Profes Interdisciplinaria Biotecnol, Mexico City 07340, DF, Mexico

来源：

TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 08期

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; ONE-POT SYNTHESIS; CHIRAL AUXILIARY; ENANTIOSELECTIVE ADDITION; DIETHYLZINC; LIGANDS; ALCOHOLS; (S; S)-(+)-PSEUDOEPHEDRINE; PSEUDOEPHEDRINE; ALDEHYDES;

D O I：

10.1016/j.tetasy.2010.05.007

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The reaction of chlorodeoxyephedrine hydrochlorides with one, two, and three molar equivalents of base was studied. Isochlorodeoxypseudoepherines were identified and assigned by H-1 and C-13 NMR data as intermediate compounds in the formation of cis-aziridines. Erythro and threo ephedrinethylethers were isolated as new compounds and analyzed by spectroscopic data. In addition, the erythro isomer was studied by X-ray diffraction. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：909 / 913

页数：5

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