ESR1 Mutations: From Benchside to Bedside

被引：0

作者：

Massard, V. ^{[1
]}

Harle, A. ^{[2
]}

Uwer, L. ^{[1
]}

Merlin, J. -L. ^{[2
]}

机构：

[1] Inst Cancerol Lorraine, Dept Oncol Med, F-54519 Vandoeuvre Les Nancy, France

[2] Univ Lorraine, CNRS, UMR 7039, Serv Biopathol,Inst Cancerol Lorraine,CRAN, Nancy, France

来源：

ONCOLOGIE | 2019年 / 21卷 / 1-4期

关键词：

ESR1; mutations; Endocrine resistance; Aromatase inhibitors; Circulating tumour DNA; METASTATIC BREAST-CANCER; CELL-FREE DNA;

D O I：

10.3166/onco-2019-0027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acquired endocrine resistance remains one of the main obstacles in the treatment of estrogen receptor (ER) positive, HER2 negative advanced breast cancer. Recently, activating ESR1 gene mutations affecting the ligand-binding domain have been identified as a key mechanismin aromatase inhibitor (AI) resistance. These mutations can be detected on histological samples or circulating tumour DNA, using PCR-based assays or next-generation sequencing. They induce a constitutive activation of ER, leading to acquired resistance to AI; tamoxifen, fulvestrant and targeted therapies against mTOR or CDK4/6 retain their efficacy. The use of monitoring ESR1 mutations in clinical practice is still to be defined.

引用

页码：29 / 32

页数：4

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