Antibody and B cell responses to SARS-CoV-2 infection and vaccination

被引：112

作者：

Roltgen, Katharina ^{[1
]}

Boyd, Scott D. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA

[2] Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA

来源：

CELL HOST & MICROBE | 2021年 / 29卷 / 07期

关键词：

RECEPTOR-BINDING DOMAIN; NEUTRALIZING ANTIBODIES; IMMUNITY; MEMORY; SPIKE; PERSIST; B.1.351;

D O I：

10.1016/j.chom.2021.06.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibodies, and the B cell and plasma cell populations responsible for their production, are key components of the human immune system's response to SARS-CoV-2, which has caused the coronavirus disease 2019 (COVID-19) pandemic. Here, we review findings addressing the nature of antibody responses against SARS-CoV-2 and their role in protecting from infection or modulating COVID-19 disease severity. In just over a year, much has been learned, and replicated in independent studies, about human immune responses to this pathogen, contributing to the development of effective vaccines. Nevertheless, important questions remain about the duration and effectiveness of antibody responses, differences between immunity derived from infection compared to vaccination, the cellular basis for serological findings, and the extent to which viral variants will escape from current immunity.

引用

页码：1063 / 1075

页数：13

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