Thyroid autoimmunity in adverse fertility and pregnancy outcomes: Timing of assisted reproductive technology in AITD women

被引：13

作者：

Wang, Jia-Wei ^{[1
]}

Liao, Xiao-Xian ^{[2
]}

Li, Tuo ^{[2
]}

机构：

[1] Nantong Univ, Dept Obstet & Gynecol, Nantong Matern & Child Hlth Care Hosp, Nantong 226018, Jiangsu, Peoples R China

[2] Naval Med Univ, Changzheng Hosp, Dept Endocrinol, 450 Fengyang Rd, Shanghai 200003, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE | 2021年 / 9卷 / 02期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

autoimmune thyroid diseases; AITD; Infertility; Assisted reproductive technology; ART; IN-VITRO FERTILIZATION; ANTIBODY-POSITIVE WOMEN; LIVE-BIRTH-RATE; RECURRENT MISCARRIAGE; LEVOTHYROXINE TREATMENT; EUTHYROID WOMEN; SUBCLINICAL HYPOTHYROIDISM; PRETERM DELIVERY; INFERTILE WOMEN; EMBRYO-TRANSFER;

D O I：

10.2478/jtim-2021-0001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thyroid autoimmunity (TAI) is prevalent in women of live-birthing age and has independently been associated with complications of fertility and pregnancy, in the case of spontaneous conception or after assisted reproductive technology (ART) treatment. However, it remains challenging to identify causation between infertility and TAI, even interventional trials looking at the impact of levothyroxine (LT4) treatment on fertility and pregnancy outcomes due to differences among study results which related to small scales, impropriate study designs, enrollment criteria of infertility cause and titer/hormone concentration measurements. Furthermore, many questions remain unsettled in ART management in AITD infertile women attempt pregnancy. Therefore, further observational and interventional trials are needed more comprehensive multiple-center, double blinded, and randomized.

引用

页码：76 / 83

页数：8

共 81 条

[1] Pregnancy Outcomes in Women With Thyroid Peroxidase Antibodies [J].