Hypoxic regulation of erythropoiesis and iron metabolism

被引：260

作者：

Haase, Volker H. ^{[1
,2
,3
]}

机构：

[1] Vanderbilt Univ Sch Med, Dept Med, Nashville, TN USA

[2] Vanderbilt Univ Sch Med, Dept Canc Biol, Nashville, TN USA

[3] Vanderbilt Univ Sch Med, Dept Mol Physiol & Biophys, Nashville, TN USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2010年 / 299卷 / 01期

关键词：

erythropoietin; hypoxia; hypoxia-inducible factors; iron; red blood cells; INDUCIBLE FACTOR-I; HYDROXYLASE DOMAIN PROTEIN-2; MESSENGER-RNA; TUMOR-SUPPRESSOR; GENE-EXPRESSION; TRANSCRIPTIONAL ACTIVATION; PHYSIOLOGICAL-RESPONSES; DEPENDENT EXPRESSION; CHUVASH POLYCYTHEMIA; PROLYL-HYDROXYLASES;

D O I：

10.1152/ajprenal.00174.2010

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Haase VH. Hypoxic regulation of erythropoiesis and iron metabolism. Am J Physiol Renal Physiol 299: F1-F13, 2010. First published May 5, 2010; doi: 10.1152/ajprenal.00174.2010.-The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia. Recent insights into the molecular mechanisms that control and integrate cellular and systemic erythropoiesis-promoting hypoxia responses and their potential as a therapeutic target for the treatment of renal anemia are discussed in this review.

引用

页码：F1 / F13

页数：13

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