Hypoxic regulation of erythropoiesis and iron metabolism

被引：260
作者：
Haase, Volker H. [1 ,2 ,3 ]
机构：
[1] Vanderbilt Univ Sch Med, Dept Med, Nashville, TN USA
[2] Vanderbilt Univ Sch Med, Dept Canc Biol, Nashville, TN USA
[3] Vanderbilt Univ Sch Med, Dept Mol Physiol & Biophys, Nashville, TN USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2010年 / 299卷 / 01期
关键词：
erythropoietin; hypoxia; hypoxia-inducible factors; iron; red blood cells; INDUCIBLE FACTOR-I; HYDROXYLASE DOMAIN PROTEIN-2; MESSENGER-RNA; TUMOR-SUPPRESSOR; GENE-EXPRESSION; TRANSCRIPTIONAL ACTIVATION; PHYSIOLOGICAL-RESPONSES; DEPENDENT EXPRESSION; CHUVASH POLYCYTHEMIA; PROLYL-HYDROXYLASES;
D O I：
10.1152/ajprenal.00174.2010
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Haase VH. Hypoxic regulation of erythropoiesis and iron metabolism. Am J Physiol Renal Physiol 299: F1-F13, 2010. First published May 5, 2010; doi: 10.1152/ajprenal.00174.2010.-The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia. Recent insights into the molecular mechanisms that control and integrate cellular and systemic erythropoiesis-promoting hypoxia responses and their potential as a therapeutic target for the treatment of renal anemia are discussed in this review.
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页码：F1 / F13
页数：13
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