Reconstruction of intestinal microecology of type 2 diabetes by fecal microbiota transplantation: Why and how

被引：20
作者：
Hou, Kaijian [1 ,2 ]
Zhang, Shuo [1 ,2 ]
Wu, Zezhen [1 ,2 ]
Zhu, Dan [1 ]
Chen, Fengwu [1 ]
Lei, Zi-Ning [3 ]
Liu, Weiting [4 ,5 ]
Xiao, Chuanxing [6 ]
Chen, Zhe-Sheng [3 ]
机构：
[1] Shantou Univ, Longhu Hosp, Dept Endocrine & Metab Dis, Affiliated Hosp 1,Med Coll, Shantou, Guangdong, Peoples R China
[2] Shantou Univ, Dept Endocrine & Metab Dis, Med Coll, Shantou, Guangdong, Peoples R China
[3] St Johns Univ, Dept Pharmaceut Sci, Coll Pharm & Hlth Sci, Queens, NY USA
[4] Anhui Univ Chinese Med, Coll Nursing, Dept Teaching, Hefei, Anhui, Peoples R China
[5] Anhui Univ Chinese Med, Coll Nursing, Res Sect, Hefei, Anhui, Peoples R China
[6] Fujian Univ Tradit Chinese Med, Dept Pharm, Coll Tradit Chinese Med, Fuzhou, Fujian, Peoples R China
来源：
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES | 2022年 / 22卷 / 03期
关键词：
Fecal transplant; intestinal microecology; type; 2; diabetes; stjohns; edu; CHAIN FATTY-ACIDS; GUT MICROBIOTA; BILE-ACIDS; INSULIN SENSITIVITY; METABOLIC SYNDROME; OBESITY; GLUCOSE; DIET; METFORMIN; INCREASES;
D O I：
10.17305/bjbms.2021.6323
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Type 2 diabetes (T2D) is a chronic metabolic disease characterized by hyperglycemia due to insulin resistance. Mounting evidence has correlated T2D to alterations in the composition of gut microbiota. Accordingly, targeting the gut microbiota has become an emerging strategy for T2D management. The aim of this article is to get a better insight into the rationale for targeting gut microbiota in T2D treatment. Thus, we herein reviewed the change of gut microbiota composition in T2D, factors shaping gut microbiota, and potential mechanisms behind the contribution of gut microbiota to T2D pathogenesis. At present, it has become possible to use intestinal microorganism capsules, bacteria liquid, and other preparations to carry out fecal microbiota transplantation for the treatment and intervention of T2D with insulin resistance and immune-mediated type 1 diabetes.
引用
收藏
页码：315 / 325
页数：11
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