Synthesis of 198Au nanoparticles sub 10 nm due optimization on local dose by Monte Carlo simulations for cancer treatment

被引：2

作者：

Zutta Villate, Julian Mateo ^{[1
]}

Rojas, Jessika Viviana ^{[2
]}

Hahn, Marc Benjamin ^{[3
,4
]}

Anselmo Puerta, Jorge ^{[5
]}

机构：

[1] Pontificia Univ Javeriana, Dept Phys, Bogota, DC, Colombia

[2] Virginia Commonwealth Univ, Dept Mech & Nucl Engn, Richmond, VA 23284 USA

[3] Bundesanstalt Mat Forsch & Prufung BAM, D-12205 Berlin, Germany

[4] Univ Nacl Colombia, Medellin, Colombia

[5] Univ Nacl Colombia, Sch Phys, Medellin, Colombia

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2022年 / 331卷 / 07期

关键词：

Dose enhancement; Nuclear Medicine; Radioactive gold nanoparticles; Nanomaterial synthesis; Neutron activation; ULTRASMALL GOLD NANOPARTICLES; SIZE; THERAPY; TOXICITY; CELLS; TOPAS;

D O I：

10.1007/s10967-022-08355-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

To enhance the biological effects of radiation damage in cancerous cells, we present an alternative approach to the use of gold nanoparticles (AuNP), focusing on the synthesis and characterization of highly monodisperse, spherical radioactive gold nanoparticles (AuNP)-Au-198. The size of the AuNP size was optimized with the help of Geant4/TOPAS particle scattering simulations, and energy deposition per nm(3) per decay for varying radii (2-10 nm) was evaluated. This work is the foundation for ongoing experimental work to evaluate cell death induced by (AuNP)-Au-198 which aims for the use of radioactive gold nanoparticles in cancer treatment.

引用

页码：3033 / 3041

页数：9

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