Ubiquitin, hormones and biotic stress in plants

被引:412
作者
Dreher, Kate [1 ]
Callis, Judy [1 ]
机构
[1] Univ Calif Davis, Sect Mol & Cellular Biol, Plant Biol Grad Grp Program, Davis, CA 95616 USA
关键词
ubiquitin; E3; ligase; RING; U-Box; SCF; CRL; ubiquitylation; regulated proteolysis; plant defence; hormonal signalling; biotic stress; pathogen response;
D O I
10.1093/aob/mcl255
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Background The covalent attachment of ubiquitin to a substrate protein changes its fate. Notably, proteins typically tagged with a lysine48-linked polyubiquitin chain become substrates for degradation by the 26S proteasome. In recent years many experiments have been performed to characterize the proteins involved in the ubiquitylation process and to identify their substrates, in order to understand better the mechanisms that link specific protein degradation events to regulation of plant growth and development. Scope This review focuses on the role that ubiquitin plays in hormone synthesis, hormonal signalling cascades and plant defence mechanisms. Several examples are given of how targeted degradation of proteins affects downstream transcriptional regulation of hormone-responsive genes in the auxin, gibberellin, abscisic acid, ethylene and jasmonate signalling pathways. Additional experiments suggest that ubiquitin-mediated proteolysis may also act upstream of the hormonal signalling cascades by regulating hormone biosynthesis, transport and perception. Moreover, several experiments demonstrate that hormonal cross-talk can occur at the level of proteolysis. The more recently established role of the ubiquitin/proteasome system (UPS) in defence against biotic threats is also reviewed. Conclusions The UPS has been implicated in the regulation of almost every developmental process in plants, from embryogenesis to floral organ production probably through its central role in many hormone pathways. More recent evidence provides molecular mechanisms for hormonal cross-talk and links the UPS system to biotic defence responses.
引用
收藏
页码:787 / 822
页数:36
相关论文
共 351 条
[61]   The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation [J].
Dill, A ;
Thomas, SG ;
Hu, JH ;
Steber, CM ;
Sun, TP .
PLANT CELL, 2004, 16 (06) :1392-1405
[62]   An auxin-inducible f-box protein CEGENDUO negatively regulates auxin-mediated lateral root formation in Arabidopsis [J].
Dong, L ;
Wang, L ;
Zhang, Y ;
Zhang, YS ;
Deng, XW ;
Xue, YB .
PLANT MOLECULAR BIOLOGY, 2006, 60 (04) :599-615
[63]   NPR1, all things considered [J].
Dong, XN .
CURRENT OPINION IN PLANT BIOLOGY, 2004, 7 (05) :547-552
[64]   The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis [J].
Doronkin, S ;
Djagaeva, I ;
Beckendorf, SK .
DEVELOPMENTAL CELL, 2003, 4 (05) :699-710
[65]   Post-translational regulation in plants employing a diverse set of polypeptide tags [J].
Downes, B ;
Vierstra, RD .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2005, 33 :393-399
[66]   The HECT ubiquitin-protein ligase (UPL) family in Arabidopsis:: UPL3 has a specific role in trichome development [J].
Downes, BP ;
Stupar, RM ;
Gingerich, DJ ;
Vierstra, RD .
PLANT JOURNAL, 2003, 35 (06) :729-742
[67]   Stability in vitro of the 69K movement protein of Turnip yellow mosaic virus is regulated by the ubiquitin-mediated proteasome pathway [J].
Drugeon, G ;
Jupin, I .
JOURNAL OF GENERAL VIROLOGY, 2002, 83 :3187-3197
[68]   Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules [J].
Duncan, Lidia M. ;
Piper, Sian ;
Dodd, Roger B. ;
Saville, Mark K. ;
Sanderson, Chris M. ;
Luzio, J. Paul ;
Lehner, Paul J. .
EMBO JOURNAL, 2006, 25 (08) :1635-1645
[69]   cDNA-AFLP reveals a striking overlap in race-specific resistance and wound response gene expression profiles [J].
Durrant, WE ;
Rowland, O ;
Piedras, P ;
Hammond-Kosack, KE ;
Jones, JDG .
PLANT CELL, 2000, 12 (06) :963-977
[70]   Systemic acquired resistance [J].
Durrant, WE ;
Dong, X .
ANNUAL REVIEW OF PHYTOPATHOLOGY, 2004, 42 :185-209