Overcoming Acquired PD-1/PD-L1 Resistance with CD38 Blockade

被引:27
作者
Mittal, Deepak [1 ]
Vijayan, Dipti [1 ]
Smyth, Mark J. [1 ]
机构
[1] QIMR Berghofer Med Res Inst, Immunol Canc & Infect Lab, Herston, Qld, Australia
关键词
THERAPY; CELLS;
D O I
10.1158/2159-8290.CD-18-0798
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Overexpression of CD38 after PD-1/PD-L1 blockade increases extracellular adenosine levels and may contribute to acquired resistance to anti-PD-1/PD-L1 therapy. (C) 2018 AACR.
引用
收藏
页码:1066 / 1068
页数:3
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