A new paradigm for the regulation of the mammalian ribosomal RNA genes

被引：9

作者：

Moss, T.

Stefanovsky, V.

Langlois, F.

Gagnon-Kugler, T.

机构：

[1] Univ Laval, Canc Res Ctr, CHUQ, HDQ, Laval, PQ G1R 35S, Canada

[2] Univ Laval, Dept Med Biol, CHUQ, HDQ, Laval, PQ G1R 35S, Canada

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷

关键词：

growth factor; mammalian cell; ribosomal RNA gene; RNA polymerase I; rRNA; transcription elongation;

D O I：

10.1042/BST0341079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ribosome assembly occurs co-transcriptionally on the rRNA genes. This process requires the co-ordinated expression and assembly of many hundreds of proteins and is finely tuned to cell and organism growth. Coordinate regulation of the rRNA genes and the ribosomal protein genes is therefore essential for high-fidelity ribosome assembly. Recent work shows that rRNA gene transcription is regulated at the level of elongation via the mitogen-activated protein kinase pathway. We argue that this may provide an explanation for the high fidelity of ribosome assembly.

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页码：1079 / 1081

页数：3

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