Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer

被引：212

作者：

Amatu, A. ^{[1
]}

Sartore-Bianchi, A. ^{[1
,2
]}

Bencardino, K. ^{[1
]}

Pizzutilo, E. G. ^{[1
,2
]}

Tosi, F. ^{[1
,2
]}

Siena, S. ^{[1
,2
]}

机构：

[1] Grande Osped Metropolitano Niguarda, Niguarda Canc Ctr, Dept Hematol & Oncol, Piazza Osped Maggiore 3, I-20162 Milan, Italy

[2] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy

来源：

ANNALS OF ONCOLOGY | 2019年 / 30卷

基金：

欧盟地平线“2020”;

关键词：

TRK; tropomyosin receptor kinase; NTRK gene fusions; TRK fusion cancer; NERVE GROWTH-FACTOR; TYROSINE PROTEIN-KINASE; NEUROTROPHIC FACTOR; MESOBLASTIC NEPHROMA; TARGETED THERAPY; CONGENITAL INSENSITIVITY; INHIBITOR ENTRECTINIB; PROTOONCOGENE PRODUCT; ACQUIRED-RESISTANCE; HIGH-FREQUENCY;

D O I：

10.1093/annonc/mdz383

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by NTRK genes and have a role in the development and normal functioning of the nervous system. Since the discovery of an oncogenic NTRK gene fusion in colorectal cancer in 1986, over 80 different fusion partner genes have been identified in a wide array of adult and paediatric tumours, providing actionable targets for targeted therapy. This review describes the normal function and physiology of TRK receptors and the biology behind NTRK gene fusions and how they act as oncogenic drivers in cancer. Finally, an overview of the incidence and prevalence of NTRK gene fusions in various types of cancers is discussed.

引用

页码：VIII5 / VIII15

页数：11

共 122 条

[81] CLONING AND CHROMOSOMAL LOCALIZATION OF THE HUMAN TRK-B TYROSINE KINASE RECEPTOR GENE (NTRK2) [J].

NAKAGAWARA, A ;

LIU, XC ;

IKEGAKI, N ;

WHITE, PS ;

YAMASHIRO, DJ ;

NYCUM, LM ;

BIEGEL, JA ;

BRODEUR, GM .

GENOMICS, 1995, 25 (02) :538-546

[82] Trk receptor tyrosine kinases: A bridge between cancer and neural development [J].

Nakagawara, A .

CANCER LETTERS, 2001, 169 (02) :107-114

[83]

NANDA N, 2015, J CLIN ONCOL S15, V33

[84] Analysis of NTRK Alterations in Pan-Cancer Adult and Pediatric Malignancies: Implications for NTRK-Targeted Therapeutics [J].

Okamura, Ryosuke ;

Boichard, Amelie ;

Kato, Shumei ;

Sicklick, Jason K. ;

Bazhenova, Lyudmila ;

Kurzrock, Razelle .

JCO PRECISION ONCOLOGY, 2018, 2 :1-20

[85] ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer [J].

Pietrantonio, Filippo ;

Di Nicolantonio, Federica ;

Schrock, Alexa B. ;

Lee, Jeeyun ;

Tejpar, Sabine ;

Sartore-Bianchi, Andrea ;

Hechtman, Jaclyn F. ;

Christiansen, Jason ;

Novara, Luca ;

Tebbutt, Niall ;

Fuca, Giovanni ;

Antoniotti, Carlotta ;

Kim, Seung Tae ;

Murphy, Danielle ;

Berenato, Rosa ;

Morano, Federica ;

Sun, James ;

Min, Bosun ;

Stephens, Philip J. ;

Chen, Marissa ;

Cremolini, Chiara .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2017, 109 (12)

[86]

PISHVAIAN MJ, 2018, J CLIN ONCOL S4, V36

[87] Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology [J].

Qaddoumi, Ibrahim ;

Orisme, Wilda ;

Wen, Ji ;

Santiago, Teresa ;

Gupta, Kirti ;

Dalton, James D. ;

Tang, Bo ;

Haupfear, Kelly ;

Punchihewa, Chandanamali ;

Easton, John ;

Mulder, Heather ;

Boggs, Kristy ;

Shao, Ying ;

Rusch, Michael ;

Becksfort, Jared ;

Gupta, Pankaj ;

Wang, Shuoguo ;

Lee, Ryan P. ;

Brat, Daniel ;

Collins, V. Peter ;

Dahiya, Sonika ;

George, David ;

Konomos, William ;

Kurian, Kathreena M. ;

McFadden, Kathryn ;

Serafini, Luciano Neder ;

Nickols, Hilary ;

Perry, Arie ;

Shurtleff, Sheila ;

Gajjar, Amar ;

Boop, Fredrick A. ;

Klimo, Paul D., Jr. ;

Mardis, Elaine R. ;

Wilson, Richard K. ;

Baker, Suzanne J. ;

Zhang, Jinghui ;

Wu, Gang ;

Downing, James R. ;

Tatevossian, Ruth G. ;

Ellison, David W. .

ACTA NEUROPATHOLOGICA, 2016, 131 (06) :833-845

[88] Broad Detection of Alterations Predicted to Confer Lack of Benefit From EGFR Antibodies or Sensitivity to Targeted Therapy in Advanced Colorectal Cancer [J].

Rankin, Andrew ;

Klempner, Samuel J. ;

Erlich, Rachel ;

Sun, James X. ;

Grothey, Axel ;

Fakih, Marwan ;

George, Thomas J., Jr. ;

Lee, Jeeyun ;

Ross, Jeffrey S. ;

Stephens, Philip J. ;

Miller, Vincent A. ;

Ali, Siraj M. ;

Schrock, Alexa B. .

ONCOLOGIST, 2016, 21 (11) :1306-1314

[89] Neuratrophin-regulated signalling pathways [J].

Reichardt, Louis F. .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2006, 361 (1473) :1545-1564

[90] Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers [J].

Ricarte-Filho, Julio C. ;

Li, Sheng ;

Garcia-Rendueles, Maria E. R. ;

Montero-Conde, Cristina ;

Voza, Francesca ;

Knauf, Jeffrey A. ;

Heguy, Adriana ;

Viale, Agnes ;

Bogdanova, Tetyana ;

Thomas, Geraldine A. ;

Mason, Christopher E. ;

Fagin, James A. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (11) :4935-4944

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