Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer

被引：212

作者：

Amatu, A. ^{[1
]}

Sartore-Bianchi, A. ^{[1
,2
]}

Bencardino, K. ^{[1
]}

Pizzutilo, E. G. ^{[1
,2
]}

Tosi, F. ^{[1
,2
]}

Siena, S. ^{[1
,2
]}

机构：

[1] Grande Osped Metropolitano Niguarda, Niguarda Canc Ctr, Dept Hematol & Oncol, Piazza Osped Maggiore 3, I-20162 Milan, Italy

[2] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy

来源：

ANNALS OF ONCOLOGY | 2019年 / 30卷

基金：

欧盟地平线“2020”;

关键词：

TRK; tropomyosin receptor kinase; NTRK gene fusions; TRK fusion cancer; NERVE GROWTH-FACTOR; TYROSINE PROTEIN-KINASE; NEUROTROPHIC FACTOR; MESOBLASTIC NEPHROMA; TARGETED THERAPY; CONGENITAL INSENSITIVITY; INHIBITOR ENTRECTINIB; PROTOONCOGENE PRODUCT; ACQUIRED-RESISTANCE; HIGH-FREQUENCY;

D O I：

10.1093/annonc/mdz383

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by NTRK genes and have a role in the development and normal functioning of the nervous system. Since the discovery of an oncogenic NTRK gene fusion in colorectal cancer in 1986, over 80 different fusion partner genes have been identified in a wide array of adult and paediatric tumours, providing actionable targets for targeted therapy. This review describes the normal function and physiology of TRK receptors and the biology behind NTRK gene fusions and how they act as oncogenic drivers in cancer. Finally, an overview of the incidence and prevalence of NTRK gene fusions in various types of cancers is discussed.

引用

页码：VIII5 / VIII15

页数：11

共 122 条

[1] Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors [J].

Agaram, Narasimhan P. ;

Zhang, Lei ;

Sung, Yun-Shao ;

Chen, Chun-Liang ;

Chung, Catherine T. ;

Antonescu, Cristina R. ;

Fletcher, Christopher D. M. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2016, 40 (10) :1407-1416

[2] Integrated Genomic Characterization of Papillary Thyroid Carcinoma [J].

Agrawal, Nishant ;

Akbani, Rehan ;

Aksoy, B. Arman ;

Ally, Adrian ;

Arachchi, Harindra ;

Asa, Sylvia L. ;

Auman, J. Todd ;

Balasundaram, Miruna ;

Balu, Saianand ;

Baylin, Stephen B. ;

Behera, Madhusmita ;

Bernard, Brady ;

Beroukhim, Rameen ;

Bishop, Justin A. ;

Black, Aaron D. ;

Bodenheimer, Tom ;

Boice, Lori ;

Bootwalla, Moiz S. ;

Bowen, Jay ;

Bowlby, Reanne ;

Bristow, Christopher A. ;

Brookens, Robin ;

Brooks, Denise ;

Bryant, Robert ;

Buda, Elizabeth ;

Butterfield, Yaron S. N. ;

Carling, Tobias ;

Carlsen, Rebecca ;

Carter, Scott L. ;

Carty, Sally E. ;

Chan, Timothy A. ;

Chen, Amy Y. ;

Cherniack, Andrew D. ;

Cheung, Dorothy ;

Chin, Lynda ;

Cho, Juok ;

Chu, Andy ;

Chuah, Eric ;

Cibulskis, Kristian ;

Ciriello, Giovanni ;

Clarke, Amanda ;

Clayman, Gary L. ;

Cope, Leslie ;

Copland, John A. ;

Covington, Kyle ;

Danilova, Ludmila ;

Davidsen, Tanja ;

Demchok, John A. ;

DiCara, Daniel ;

Dhalla, Noreen .

CELL, 2014, 159 (03) :676-690

[3] ETV6-NTRK3 Is Expressed in a Subset of ALK-Negative Inflammatory Myofibroblastic Tumors [J].

Alassiri, Ali H. ;

Ali, Rola H. ;

Shen, Yaoqing ;

Lum, Amy ;

Strahlendorf, Caron ;

Deyell, Rebecca ;

Rassekh, Rod ;

Sorensen, Poul H. ;

Laskin, Janessa ;

Marra, Marco ;

Yip, Stephen ;

Lee, Cheng-Han ;

Ng, Tony L. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2016, 40 (08) :1051-1061

[4] NTRK gene fusions as novel targets of cancer therapy across multiple tumour types [J].

Amatu, Alessio ;

Sartore-Bianchi, Andrea ;

Siena, Salvatore .

ESMO OPEN, 2016, 1 (02)

[5] Analysis of Clinical Features of Mammary Analog Secretory Carcinoma Using the Surveillance. Epidemiology, and End Results Database [J].

Anderson, Jennifer L. ;

Haidar, Yarah M. ;

Armstrong, William B. ;

Tjoa, Tjoson .

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2019, 145 (01) :91-93

[6] ETV6 Gene Rearrangements Characterize a Morphologically Distinct Subset of Sinonasal Low-grade Non-intestinal-type Adenocarcinoma A Novel Translocation-associated Carcinoma Restricted to the Sinonasal Tract [J].

Andreasen, Simon ;

Skalova, Alena ;

Agaimy, Abbas ;

Bishop, Justin A. ;

Laco, Jan ;

Leivo, Ilmo ;

Franchi, Alessandro ;

Larsen, Stine R. ;

Erentaite, Daiva ;

Ulhoi, Benedicte P. ;

von Buchwald, Christian ;

Melchior, Linea C. ;

Michal, Michal ;

Kiss, Katalin .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2017, 41 (11) :1552-1560

[7]

[Anonymous], PEDIAT BLOOD CANC

[8] The TPM3-NTRK1 rearrangement is a recurring event in colorectal carcinoma and is associated with tumor sensitivity to TRKA kinase inhibition [J].

Ardini, Elena ;

Bosotti, Roberta ;

Borgia, Andrea Lombardi ;

De Ponti, Cristina ;

Somaschini, Alessio ;

Cammarota, Rosaria ;

Amboldi, Nadia ;

Raddrizzani, Laura ;

Milani, Andrea ;

Magnaghi, Paola ;

Ballinari, Dario ;

Casero, Daniele ;

Gasparri, Fabio ;

Banfi, Patrizia ;

Avanzi, Nilla ;

Saccardo, Maria B. ;

Alzani, Rachele ;

Bandiera, Tiziano ;

Felder, Eduard ;

Donati, Daniele ;

Pesenti, Enrico ;

Sartore-Bianchi, Andrea ;

Gambacorta, Marcello ;

Pierotti, Marco A. ;

Siena, Salvatore ;

Veronese, Silvio ;

Galvani, Arturo ;

Isacchi, Antonella .

MOLECULAR ONCOLOGY, 2014, 8 (08) :1495-1507

[9] THE TRK FAMILY OF NEUROTROPHIN RECEPTORS [J].

BARBACID, M .

JOURNAL OF NEUROBIOLOGY, 1994, 25 (11) :1386-1403

[10] THE TRK FAMILY OF TYROSINE PROTEIN-KINASE RECEPTORS [J].

BARBACID, M ;

LAMBALLE, F ;

PULIDO, D ;

KLEIN, R .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1072 (2-3) :115-127

← 1 2 3 4 5 6 7 8 9 10 →