Insulin-like growth factor binding protein-I-6 expression in activated microglia

被引：15

作者：

Chesik, D ^{[1
]}

Glazenburg, K ^{[1
]}

Wilczak, N ^{[1
]}

Geeraedts, F ^{[1
]}

De Keyser, J ^{[1
]}

机构：

[1] Univ Groningen Hosp, Dept Neurol, NL-9700 RB Groningen, Netherlands

来源：

NEUROREPORT | 2004年 / 15卷 / 06期

关键词：

insulin-like growth factor-i; insulin-like growth factor binding proteins; lipopolysaccharide; microglia;

D O I：

10.1097/00001756-200404290-00020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the CNS insulin-like growth factor-1 (IGF-1) enhances survival of neurons, promotes myelin synthesis and acts as a mitogen for microglia. The effects of IGF-1 are regulated by a family of 6 IGF binding proteins (IGFBPs). We investigated mRNA expression patterns of IGFBPs in primary rat microglia under basal conditions and after activation with lipopolysaccharide (LPS). Under basal conditions, microglia expressed IGFBP-2 to -6, whereas, IGFBP-1 could not be detected. Following 2 h treatment with LPS mRNA levels for IGFBP-4 and -6 displayed a down regulation, and IGFBP-5 became undetectable. Levels of IGFBP-2 and -3 remained unaltered. Expression patterns of IGFBPs might play an important role in regulating the autocrine/paracrine IGF-1 actions on microglia under inflammatory conditions.

引用

页码：1033 / 1037

页数：5

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