Reduction of β-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization

被引：74

作者：

Frenkel, D

Dewachter, I

Van Leuven, F

Solomon, B ^{[1
]}

机构：

[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel

[2] Katholieke Univ Leuven, Dept Human Genet, Expt Genet Grp, B-3000 Louvain, Belgium

来源：

VACCINE | 2003年 / 21卷 / 11-12期

关键词：

Alzheimer's plaque clearance; APP-transgenic mice; EFRH-epitope;

D O I：

10.1016/S0264-410X(02)00609-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibodies to the epitope EFRH, representing residues 3-6 within the beta-amyloid (Abeta) sequence, were previously shown to affect the solubility and disaggregation of Abeta fibrils in vitro. Here, we describe a novel method of immunization, using as antigen the EFRH peptide displayed on the surface of the filamentous phage. The EFRH phage evoked effective auto-immune antibodies in amyloid precursor protein [V717I] (APP[V717I]) transgenic mice that recapitulate the amyloid plaques and vascular pathology of Alzheimer's disease (AD). The immunization provoked a considerable reduction in the number of Abeta amyloid plaques in the brain of the transgenic mice and may serve as the basis for anti-Abeta vaccine. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1060 / 1065

页数：6

共 18 条

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