RNA silencing in plants

被引：1832

作者：

Baulcombe, D ^{[1
]}

机构：

[1] John Innes Ctr Plant Sci Res, Sainsbury Lab, Norwich NR4 7UH, Norfolk, England

来源：

NATURE | 2004年 / 431卷 / 7006期

关键词：

D O I：

10.1038/nature02874

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There are at least three RNA silencing pathways for silencing specific genes in plants. In these pathways, silencing signals can be amplified and transmitted between cells, and may even be self-regulated by feedback mechanisms. Diverse biological roles of these pathways have been established, including defence against viruses, regulation of gene expression and the condensation of chromatin into heterochromatin. We are now in a good position to investigate the full extent of this functional diversity in genetic and epigenetic mechanisms of genome control.

引用

页码：356 / 363

页数：8

共 87 条

[1]

ACHARD P, IN PRESS GENES DEV

[2] Regulation of flowering time and floral organ identity by a microRNA and its APETALA2-like target genes [J].

Aukerman, MJ ;

Sakai, H .

PLANT CELL, 2003, 15 (11) :2730-2741

[3] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[4] Arabidopsis HEN1:: A genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance [J].

Boutet, S ;

Vazquez, F ;

Liu, J ;

Béclin, C ;

Fagard, M ;

Gratias, A ;

Morel, JB ;

Crété, P ;

Chen, XM ;

Vaucheret, H .

CURRENT BIOLOGY, 2003, 13 (10) :843-848

[5] Viral RNA silencing suppressors inhibit the microRNA pathway at an intermediate step [J].

Chapman, EJ ;

Prokhnevsky, AI ;

Gopinath, K ;

Dolja, VV ;

Carrington, JC .

GENES & DEVELOPMENT, 2004, 18 (10) :1179-1186

[6] A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development [J].

Chen, XM .

SCIENCE, 2004, 303 (5666) :2022-2025

[7] Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase [J].

Cogoni, C ;

Macino, G .

NATURE, 1999, 399 (6732) :166-169

[8] Plants combat infection by gene silencing [J].

Covey, SN ;

AlKaff, NS ;

Langara, A ;

Turner, DS .

NATURE, 1997, 385 (6619) :781-782

[9] An RNA-Dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus [J].

Dalmay, T ;

Hamilton, A ;

Rudd, S ;

Angell, S ;

Baulcombe, DC .

CELL, 2000, 101 (05) :543-553

[10] SDE3 encodes an RNA helicase required for posttranscriptional gene silencing in Arabidopsis [J].

Dalmay, T ;

Horsefield, R ;

Braunstein, TH ;

Baulcombe, DC .

EMBO JOURNAL, 2001, 20 (08) :2069-2077

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