New concepts on diabetic retinopathy: neural versus vascular damage

被引：9

作者：

Serrarbassa, Pedro Duraes ^{[1
]}

Gomes Dias, Alana Ferreira ^{[1
]}

Vieira, Marcio Fragoso ^{[1
]}

机构：

[1] Hosp Serv Publ Estadual Sao Paulo, Setor Retina & Vitreo, Dept Oftalmol, Sao Paulo, Brazil

来源：

ARQUIVOS BRASILEIROS DE OFTALMOLOGIA | 2008年 / 71卷 / 03期

关键词：

Diabetic retinopathy/etiology; Nerve degeneration; Vascular diseases; Apoptosis; Vision/physiology;

D O I：

10.1590/S0004-27492008000300030

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Diabetic retinopathy is the leading cause of irreversible legal blindness in working-age adults. The number of people worldwide at risk of developing vision loss from diabetes is predicted to double over the next 30 years. Some elements suggest that neurodegenerative changes occur beyond vascular damage. These changes include increased apoptosis, glial cell reactivity, microglial activation, and altered glutamate metabolism, and could explain some of the functional abnormalities that begin soon after the onset of diabetes, as early changes in electroretinogram. This review article will present some evidences that point out neurodegeneration as a possible initial event in diabetic retinopathy.

引用

页码：459 / 463

页数：5

共 65 条

[51] Assessment of nerve fiber layer in diabetic patients with scanning laser polarimetry [J].