Characterization of T2☆ Heterogeneity in Human Brain White Matter

被引：69
作者：
Li, Tie-Qiang [1 ]
Yao, Bing [1 ]
van Gelderen, Peter [1 ]
Merkle, Hellmut [1 ]
Dodd, Stephen [1 ]
Talagala, Lalith [1 ]
Koretsky, Alan P. [1 ]
Duyn, Jeff [1 ]
机构：
[1] NINDS, Lab Funct & Mol Imaging, NIH, Bethesda, MD 20892 USA
来源：
MAGNETIC RESONANCE IN MEDICINE | 2009年 / 62卷 / 06期
关键词：
T(2)(star); heterogeneity; susceptibility; MRI contrast; iron; myelin; histology; HIGH-FIELD MRI; MAGNETIZATION-TRANSFER; IRON CONTENT; DISEASE; TISSUE; OLIGODENDROCYTES; FERRITIN; RAT;
D O I：
10.1002/mrm.22156
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Recent in vivo MRI studies at 7.0 T have demonstrated extensive heterogeneity of T(2)(star) relaxation in white matter of the human man brain. In order to study the origin of this heterogeneity, we performed T(2)(star) measurements at 1.5, 3.0, and 7.0 T in normal volunteers. Formalin-fixed brain tissue specimens were also studied using T(2)(star)-weighted MRI, histologic staining, chemical analysis, and electron microscopy. We found that T(2)(star) relaxation rate (R(2)(star) = 1/T(2)(star)) in white matter in living human brain is linearly dependent on the main magnetic field strength, and the T(2)(star) heterogeneity in white matter observed at 7.0 T can also be detected, albeit more weakly, at 1.5 and 3.0 T. The T(2)(star) heterogeneity exists also in white matter of the formalin-fixed brain tissue specimens, with prominent differences between the major fiber bundles such as the cingulum (CG) and the superior corona radiata. The white matter specimen with substantia difference in T(2)(star) has no significant difference in the total iron content, as determined by chemical analysis. On the other hand, evidence from histologic staining and electron microscopy demonstrates these tissue specimens have apparent difference in myelin content and microstructure. Magn Reson Med 62:1652-1657, 2009. (C) 2009 Wiley-Liss, Inc.
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页码：1652 / 1657
页数：6
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