Management of young women with early breast cancer

被引：15

作者：

Poggio, Francesca ^{[1
]}

Lambertini, Matteo ^{[2
,3
]}

Bighin, Claudia ^{[1
]}

Conte, Benedetta ^{[1
]}

Blondeaux, Eva ^{[1
]}

D'Alonzo, Alessia ^{[1
]}

Dellepiane, Chiara ^{[1
]}

Boccardo, Francesco ^{[4
,5
]}

Del Mastro, Lucia ^{[1
,5
]}

机构：

[1] Policlin San Martino IST, Dept Med Oncol, UO Oncol Med 2, Genoa, Italy

[2] Inst Jules Bordet, Dept Med Oncol, Brussels, Belgium

[3] Univ Libre Bruxelles, Brussels, Belgium

[4] Policlin San Martino IST, Dept Med Oncol, Clin Oncol Med, Genoa, Italy

[5] Univ Genoa, Sch Med, Dept Internal Med & Med Specialties DIMI, Genoa, Italy

来源：

ESMO OPEN | 2018年 / 3卷

关键词：

PRESERVATION; PREGNANCY; SUBTYPE; PHASE;

D O I：

10.1136/esmoopen-2018-000458

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is still the most frequent cancer diagnosed in women aged <= 40 years and the primary cause of death in this age group. The management of these patients needs a dedicated approach involving a multidisciplinary team that takes into account their treatment and survivorship issues. The present review aims to provide a perspective on the many challenges associated with treatment of young women with early breast cancer. We will focus on the standard (neo)adjuvant treatment, highlighting the paucity of age-specific results about the available genomic signatures, the groundbreaking landscape of adjuvant endocrine therapy and the relevant issue of the fertility preservation.

引用

页数：4

共 25 条

[1] Biology of breast cancer in young women [J].

Azim, Hatem A., Jr. ;

Partridge, Ann H. .

BREAST CANCER RESEARCH, 2014, 16 (04)

[2] Twelve-Month Estrogen Levels in Premenopausal Women With Hormone Receptor-Positive Breast Cancer Receiving Adjuvant Triptorelin Plus Exemestane or Tamoxifen in the Suppression of Ovarian Function Trial (SOFT): The SOFT-EST Substudy [J].

Bellet, Meritxell ;

Gray, Kathryn P. ;

Francis, Prudence A. ;

Lang, Istvan ;

Ciruelos, Eva ;

Lluch, Ana ;

Angel Climent, Miguel ;

Catalan, Gustavo ;

Avella, Antoni ;

Bohn, Uriel ;

Gonzalez-Martin, Antonio ;

Ferrer, Roser ;

Catalan, Roberto ;

Azaro, Analia ;

Rajasekaran, Agnita ;

Morales, Josefa ;

Vazquez, Josep ;

Fleming, Gini F. ;

Price, Karen N. ;

Regan, Meredith M. .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (14) :1584-U89

[3] Recent Trends in Breast Cancer Among Younger Women in the United States [J].

Brinton, Louise A. ;

Sherman, Mark E. ;

Carreon, J. Daniel ;

Anderson, William F. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (22) :1643-1648

[4] Fluorouracil and dose-dense chemotherapy in adjuvant treatment of patients with early-stage breast cancer: an open-label, 2 x 2 factorial, randomised phase 3 trial [J].

Del Mastro, Lucia y ;

De Placido, Sabino ;

Bruzzi, Paolo ;

De Laurentiis, Michele ;

Boni, Corrado ;

Cavazzini, Giovanna ;

Durando, Antonio ;

Turletti, Anna ;

Nistico, Cecilia ;

Valle, Enrichetta ;

Garrone, Ornella ;

Puglisi, Fabio ;

Montemurro, Filippo ;

Barni, Sandro ;

Ardizzoni, Andrea ;

Gamucci, Teresa ;

Colantuoni, Giuseppe ;

Giuliano, Mario ;

Gravina, Adriano ;

Papaldo, Paola ;

Bighin, Claudia ;

Bisagni, Giancarlo ;

Forestieri, Valeria ;

Cognetti, Francesco .

LANCET, 2015, 385 (9980) :1863-1872

[5] Cancer incidence and mortality among young adults aged 20-39 years worldwide in 2012: a population-based study [J].

Fidler, Miranda M. ;

Gupta, Sumit ;

Soerjomataram, Isabelle ;

Ferlay, Jacques ;

Steliarova-Foucher, Eva ;

Bray, Freddie .

LANCET ONCOLOGY, 2017, 18 (12) :1579-1589

[6] Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer [J].

Francis, P. A. ;

Pagani, O. ;

Fleming, G. F. ;

Walley, B. A. ;

Colleoni, M. ;

Lang, I. ;

Gomez, H. L. ;

Tondini, C. ;

Ciruelos, E. ;

Burstein, H. J. ;

Bonnefoi, H. R. ;

Bellet, M. ;

Martino, S. ;

Geyer, C. E., Jr. ;

Goetz, M. P. ;

Stearns, V. ;

Pinotti, G. ;

Puglisi, F. ;

Spazzapan, S. ;

Climent, M. A. ;

Pavesi, L. ;

Ruhstaller, T. ;

Davidson, N. E. ;

Coleman, R. ;

Debled, M. ;

Buchholz, S. ;

Ingle, J. N. ;

Winer, E. P. ;

Maibach, R. ;

Rabaglio-Poretti, M. ;

Ruepp, B. ;

Di Leo, A. ;

Coates, A. S. ;

Gelber, R. D. ;

Goldhirsch, A. ;

Regan, M. M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (02) :122-137

[7] Emerging Data and Current Challenges for Young, Old, Obese, or Male Patients with Breast Cancer [J].

Freedman, Rachel A. ;

Partridge, Ann H. .

CLINICAL CANCER RESEARCH, 2017, 23 (11) :2647-2654

[8]

Gray R, 2018, CANCER RES, V78

[9] Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer [J].

Hershman, Dawn L. ;

Shao, Theresa ;

Kushi, Lawrence H. ;

Buono, Donna ;

Tsai, Wei Yann ;

Fehrenbacher, Louis ;

Kwan, Marilyn ;

Gomez, Scarlett Lin ;

Neugut, Alfred I. .

BREAST CANCER RESEARCH AND TREATMENT, 2011, 126 (02) :529-537

[10]

Lambertini M, 2018, CURR OPIN ONCOL, V1

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