Complement Inhibitors in Clinical Trials for Glomerular Diseases

被引：94

作者：

Zipfel, Peter F. ^{[1
,2
]}

Wiech, Thorsten ^{[3
]}

Rudnick, Ramona ^{[1
]}

Afonso, Sara ^{[1
]}

Person, Fermin ^{[3
]}

Skerka, Christine ^{[1
]}

机构：

[1] Leibniz Inst Nat Prod Res & Infect Biol, Dept Infect Biol, Jena, Germany

[2] Friedrich Schiller Univ, Jena, Germany

[3] Univ Hosp Hamburg Eppendorf, Inst Pathol, Hamburg, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

关键词：

inhibitors; clinical trials; glomerular disease; C3; glomerulopathy; complement; ANCA; aHUS; DOMAIN-CONTAINING; 7A; H-RELATED PROTEINS; IGA NEPHROPATHY; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; GENETIC-VARIANTS; C-TERMINUS; ECULIZUMAB; AUTOANTIBODIES; INSIGHTS; CFHR1;

D O I：

10.3389/fimmu.2019.02166

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune complex membranoproliferative glomerulonephritis, ischemic reperfusion injury, lupus nephritis, membranous nephropathy, and chronic transplant mediated glomerulopathy. Here we summarize ongoing clinical trials of complement inhibitors in nine glomerular diseases and show which inhibitors are used in trials for these renal disorders (http://clinicaltrials.gov).

引用

页数：13

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