Asymmetric cinnamylation of N-tert-butanesulfinyl imines with cinnamyl acetates: total syntheses of (+)-lycoricidine and (+)-7-deoxypancratistatin

被引：27

作者：

Cai, Sen-Lin ^{[1
]}

Yuan, Bin-Hua ^{[1
]}

Jiang, Yi-Xiang ^{[1
]}

Lin, Guo-Qiang ^{[1
]}

Sun, Xing-Wen ^{[1
]}

机构：

[1] Fudan Univ, Dept Chem, 220 Handan Rd, Shanghai 200433, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 25期

基金：

中国国家自然科学基金;

关键词：

INDIUM-MEDIATED ALLYLATION; GLYOXYLIC OXIME ETHER; ALPHA-AMINO-ACIDS; AMARYLLIDACEAE ALKALOIDS; NARCICLASINE ALKALOIDS; CARBONYL ALLYLATION; UMPOLUNG ALLYLATION; EFFICIENT SYNTHESIS; ALLYLIC ALCOHOLS; DERIVATIVES;

D O I：

10.1039/c7cc00108h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Highly diastereoselective palladium catalyzed cinnamylation of N-tert-butanesulfinyl imines with cinnamyl acetates has been established to provide enantioenriched beta-aryl homoallylic amines. The synthetic application of this stragety has been successfully demonstrated in the concise total syntheses of antitumor natural products (+)-lycoricidine and (+)-7-deoxypancratistatin.

引用

页码：3520 / 3523

页数：4

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