The Role of B Cells and B Cell Therapies in Immune-Mediated Liver Diseases

被引：29
作者：
Cargill, Tamsin [1 ]
Culver, Emma L. [2 ]
机构：
[1] Univ Oxford, Nuffield Dept Med, Peter Medawar Bldg Pathogen Res, Oxford, England
[2] John Radcliffe Hosp, Oxford Liver Unit, Oxford, England
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金：
英国惠康基金;
关键词：
IgG4-related disease; autoimmune hepatitis; primary biliary cholangitis (PBC); primary sclerosing cholangites (PSC); B cell; Rituximab; PRIMARY BILIARY CHOLANGITIS; IGG4-RELATED DISEASE; T-CELLS; PATHOGENESIS; DYSFUNCTION; IGG(4)(+); SUBSETS; SAFETY;
D O I：
10.3389/fimmu.2021.661196
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
B cells form a branch of the adaptive immune system, essential for the body's immune defense against pathogens. B cell dysfunction has been implicated in the pathogenesis of immune mediated liver diseases including autoimmune hepatitis, IgG4-related hepatobiliary disease, primary biliary cholangitis and primary sclerosing cholangitis. B cells may initiate and maintain immune related liver diseases in several ways including the production of autoantibodies and the activation of T cells via antigen presentation or cytokine production. Here we comprehensively review current knowledge on B cell mechanisms in immune mediated liver diseases, exploring disease pathogenesis, B cell therapies, and novel treatment targets. We identify key areas where future research should focus to enable the development of targeted B cell therapies.
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页数：16
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共 178 条
[1]   Immunoglobulin G4: an odd antibody [J].
Aalberse, R. C. ;
Stapel, S. O. ;
Schuurman, J. ;
Rispens, T. .
CLINICAL AND EXPERIMENTAL ALLERGY, 2009, 39 (04) :469-477
[2]   Interleukin-21 plays a critical role in the pathogenesis and severity of type I autoimmune hepatitis [J].
Abe, Kazumichi ;
Takahashi, Atsushi ;
Imaizumi, Hiromichi ;
Hayashi, Manabu ;
Okai, Ken ;
Kanno, Yukiko ;
Watanabe, Hiroshi ;
Ohira, Hiromasa .
SPRINGERPLUS, 2016, 5
[3]   Safety and tolerability of inebilizumab (MEDI-551), an anti-CD19 monoclonal antibody, in patients with relapsing forms of multiple sclerosis: Results from a phase 1 randomised, placebo-controlled, escalating intravenous and subcutaneous dose study [J].
Agius, Mark A. ;
Klodowska-Duda, Gabriela ;
Maciejowski, Maciej ;
Potemkowski, Andrzej ;
Li, Jing ;
Patra, Kaushik ;
Wesley, Jacob ;
Madani, Soraya ;
Barron, Gerard ;
Katz, Eliezer ;
Flor, Armando .
MULTIPLE SCLEROSIS JOURNAL, 2019, 25 (02) :235-245
[4]   Enhanced IgG4 production by follicular helper 2 T cells and the involvement of follicular helper 1 T cells in the pathogenesis of IgG4-related disease [J].
Akiyama, Mitsuhiro ;
Yasuoka, Hidekata ;
Yamaoka, Kunihiro ;
Suzuki, Katsuya ;
Kaneko, Yuko ;
Kondo, Harumi ;
Kassai, Yoshiaki ;
Koga, Keiko ;
Miyazaki, Takahiro ;
Morita, Rimpei ;
Yoshimura, Akihiko ;
Takeuchi, Tsutomu .
ARTHRITIS RESEARCH & THERAPY, 2016, 18
[5]   Brief Report Number of Circulating Follicular Helper 2 T Cells Correlates With IgG4 and Interleukin-4 Levels and Plasmablast Numbers in IgG4-Related Disease [J].
Akiyama, Mitsuhiro ;
Suzuki, Katsuya ;
Yamaoka, Kunihiro ;
Yasuoka, Hidekata ;
Takeshita, Masaru ;
Kaneko, Yuko ;
Kondo, Harumi ;
Kassai, Yoshiaki ;
Miyazaki, Takahiro ;
Morita, Rimpei ;
Yoshimura, Akihiko ;
Takeuchi, Tsutomu .
ARTHRITIS & RHEUMATOLOGY, 2015, 67 (09) :2476-2481
[6]   B cell memory: building two walls of protection against pathogens [J].
Akkaya, Munir ;
Kwak, Kihyuck ;
Pierce, Susan K. .
NATURE REVIEWS IMMUNOLOGY, 2020, 20 (04) :229-238
[7]   Belimumab is a promising third-line treatment option for refractory autoimmune hepatitis [J].
Arvaniti, Pinelopi ;
Giannoulis, George ;
Gabeta, Stella ;
Zachou, Kalliopi ;
Koukoulis, George K. ;
Dalekos, George N. .
JHEP REPORTS, 2020, 2 (04)
[8]   Depletion of B cells induces remission of autoimmune hepatitis in mice through reduced antigen presentation and help to T cells [J].
Beland, Kathie ;
Marceau, Gabriel ;
Labardy, Agathe ;
Bourbonnais, Sara ;
Alvarez, Fernando .
HEPATOLOGY, 2015, 62 (05) :1511-1523
[9]   Disease-specific cross-reactivity between mimicking peptides of heat shock protein of mycobacterium gordonae and dominant epitope of E2 subunit of pyruvate dehydrogenase is common in Spanish but not British patients with primary biliary cirrhosis [J].
Bogdanos, DP ;
Pares, A ;
Baum, H ;
Caballeria, L ;
Rigopoulou, EI ;
Ma, Y ;
Burroughs, AK ;
Rodes, J ;
Vergani, D .
JOURNAL OF AUTOIMMUNITY, 2004, 22 (04) :353-362
[10]   Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis [J].
Bogdanos, DP ;
Baum, H ;
Grasso, A ;
Okamoto, M ;
Butler, P ;
Ma, Y ;
Rigopoulou, E ;
Montalto, P ;
Davies, ET ;
Burroughs, AK ;
Vergani, D .
JOURNAL OF HEPATOLOGY, 2004, 40 (01) :31-39
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