Morin: A Promising Natural Drug

被引:201
作者
Caselli, Anna [1 ]
Cirri, Paolo [1 ]
Santi, Alice [1 ]
Paoli, Paolo [1 ]
机构
[1] Univ Florence, Dept Expt & Clin Biomed Sci Mario Serio, I-50134 Florence, Italy
关键词
Morin; flavonoid; polyphenol; natural drug; anti-oxidant; anti-diabetic; anti-inflammatory; FLAVONOID-MEDIATED INHIBITION; OXIDATIVE STRESS; P-GLYCOPROTEIN; PSIDIUM-GUA[!text type='JAVA']JAVA[!/text; NITRIC-OXIDE; IN-VITRO; ANTIINFLAMMATORY ACTIVITY; CARBOHYDRATE-METABOLISM; ANTIBACTERIAL ACTIVITY; MULTIDRUG-RESISTANCE;
D O I
10.2174/0929867323666160106150821
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of numerous plants. Several evidence have demonstrated that Morin could have a beneficial effect on several human diseases. In fact, Morin exerts antioxidant, antidiabetic, anti-inflammatory, antitumoral, antihypertensive, antibacterial, hypouricemic, and neuroprotective effects, by modulating the activity of many enzymes. In some cases, Morin shows a systemic protective action, reducing negative side effects of several drugs, without interfering with their functions. In addition, in vitro and in vivo studies demonstrated that Morin exhibits very low toxicity levels and its chronic administration is well tolerated. All these findings suggest that Morin could be used, either alone or in combination with other drugs, to prevent many human pathologies.
引用
收藏
页码:774 / 791
页数:18
相关论文
共 171 条
[41]   Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1 [J].
Gupta, Subash C. ;
Phromnoi, Kanokkarn ;
Aggarwal, Bharat B. .
BIOCHEMICAL PHARMACOLOGY, 2013, 85 (07) :898-912
[42]   Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling [J].
Haase, H ;
Maret, W .
EXPERIMENTAL CELL RESEARCH, 2003, 291 (02) :289-298
[43]   Natural products in drug discovery [J].
Harvey, Alan L. .
DRUG DISCOVERY TODAY, 2008, 13 (19-20) :894-901
[44]   Effects of flavonoids on rat aortic smooth muscle contractility: Structure-activity relationships [J].
Herrera, MD ;
Zarzuelo, A ;
Jimenez, J ;
Marhuenda, E ;
Duarte, J .
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1996, 27 (02) :273-277
[45]   Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450 [J].
Hodek, P ;
Trefil, P ;
Stiborová, M .
CHEMICO-BIOLOGICAL INTERACTIONS, 2002, 139 (01) :1-21
[46]   Dietary flavonoids: Intake, health effects and bioavailability [J].
Hollman, PCH ;
Katan, MB .
FOOD AND CHEMICAL TOXICOLOGY, 1999, 37 (9-10) :937-942
[47]  
Hong H, 2004, KOREAN J PHARMACOGNO, V35, P16
[48]   Enhanced systemic availability of methotrexate in the presence of morin in rats [J].
Hong, Soon Sun ;
Jin, Ming-Ji ;
Han, Hyo-Kyung .
BIOPHARMACEUTICS & DRUG DISPOSITION, 2008, 29 (04) :189-193
[49]  
Hou Y. C., 2003, MID TAIWAN J MED, V8, P134
[50]   Morin inhibits 12-O-tetradecanoylphorbol-13-acetate-induced hepatocellular transformation via activator protein 1 signaling pathway and cell cycle progression [J].
Hsiang, CY ;
Wu, SL ;
Ho, TY .
BIOCHEMICAL PHARMACOLOGY, 2005, 69 (11) :1603-1611