Roles and Functions of Exosomal Non-coding RNAs in Vascular Aging

被引：47
作者：
Ni, Yu-Qing [1 ]
Lin, Xiao [1 ]
Zhan, Jun-Kun [1 ]
Liu, You-Shuo [1 ]
机构：
[1] Cent S Univ, Xiangya Hosp 2, Inst Aging & Geriatr, Dept Geriatr, Changsha 410011, Hunan, Peoples R China
来源：
AGING AND DISEASE | 2020年 / 11卷 / 01期
基金：
中国国家自然科学基金;
关键词：
exosomes; endothelial cells; vascular smooth muscle cells; vascular aging; vascular diseases; SMOOTH-MUSCLE-CELLS; ACUTE MYOCARDIAL-INFARCTION; ENDOTHELIAL-CELLS; DOWN-REGULATION; HEART-FAILURE; GENOME REGULATION; IN-VITRO; MICRORNAS; PROLIFERATION; ANGIOGENESIS;
D O I：
10.14336/AD.2019.0402
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aging is a progressive loss of physiological integrity and functionality process which increases susceptibility and mortality to diseases. Vascular aging is a specific type of organic aging. The structure and function changes of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are the main cause of vascular aging, which could influence the threshold, process, and severity of vascular related diseases. Accumulating evidences demonstrate that exosomes serve as novel intercellular information communicator between cell to cell by delivering variety biologically active cargos, especially exosomal non-coding RNAs (ncRNAs), which are associated with most of aging-related biological and functional disorders. In this review, we will summerize the emerging roles and mechanisms of exosomal ncRNAs in vascular aging and vascular aging related diseases, focusing on the role of exosomal miRNAs and lncRNAs in regulating the functions of ECs and VSMCs. Moreover, the relationship between the ECs and VSMCs linked by exosomes, the potential diagnostic and therapeutic application of exosomes in vascular aging and the clinical evaluation and treatment of vascular aging and vascular aging related diseases will also be discussed.
引用
收藏
页码：164 / 178
页数：15
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