New inhibitor against nuclear factor of activated T cells transcription from Ribes fasciculatum var. chinensei

被引：17

作者：

Dat, NT ^{[1
]}

Cai, XF ^{[1
]}

Shen, QH ^{[1
]}

Lee, IS ^{[1
]}

Kim, YH ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 01期

关键词：

Ribes fasciculatum var. chinense; saxifragaceae; NFAT transcription factor;

D O I：

10.1248/cpb.53.114

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new compounds were isolated from the stem and twigs of Ribes fasciculatum var. chinense and their structures were identified to be threo-(7S,8R)-1-(4-hydroxyphenyl)-2-[4-(E)-propenylphenoxy]-propan-1-ol (1), and 5,4'-dihydroxy-7-methoxyflavone-3-O-[alpha-L-rhamnopyranosyl(1-->3)-O-alpha-L-rhamnopyranosyl(1-->6)-O-beta-D-glucopyranoside] (2). With nine other known components, they were tested on inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor. Compound I showed a potent inhibitory activity (IC50= 15.6 mum), while compounds 4, 5 and 9 showed moderate inhibitory activity (IC50 22.4, 24.5 and 25.7 mum, respectively).

引用

页码：114 / 117

页数：4

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