Land degradation imposes a great threat to the world. It is not merely an environmental issue, but also a social and economic problem. Land desertification is among the main aspects of environment changes in the source region of the Yellow River. Previous studies focused on water resource utilization and soil erosion, but land degradation in the source region of the Yellow River even the whole Qinghai-Xizang Plateau received little attention. Based on the data obtained by field investigation and TM satellite images of 2000, this study provides the classification and evaluation information of the land degradation in the source region of the Yellow River. There are six types of land degradation in this region: water erosion in the northern mountains around the Gonghe Basin, sandy desertification in the Gonghe Basin and Upland Plain Area, aridization in the lower reaches, salinization in the Gonghe Basin, vegetation degradation in the intramontance basin and freezing and thawing erosion in the high mountains. The total degraded area is 34,429.6 km(2), making up 37.5% of the land in the study area. Finally, land degradation in the source region of the Yellow River was evaluated according to changes in the physical structure and chemical component of soils, land productivity, secondary soil salt and water conditions.