Combined application of genetic and polygenic risk scores for type 1 diabetes risk prediction

被引：2

作者：

Qu, Hui-Qi ^{[1
]}

Qu, Jingchun ^{[1
]}

Bradfield, Jonathan ^{[2
]}

Glessner, Joseph ^{[1
]}

Chang, Xiao ^{[1
]}

March, Michael ^{[1
]}

Mentch, Frank D. ^{[1
]}

Roizen, Jeffrey D. ^{[3
]}

Connolly, John J. ^{[1
]}

Sleiman, Patrick ^{[1
,4
]}

Hakonarson, Hakon ^{[1
,4
,5
]}

机构：

[1] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA

[2] Quantinuum Res LLC, San Diego, CA USA

[3] Univ Penn, Perelman Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[4] Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA

[5] Childrens Hosp Philadelphia, Div Pulm Med, Philadelphia, PA 19104 USA

来源：

DIABETES OBESITY & METABOLISM | 2021年 / 23卷 / 08期

关键词：

D O I：

10.1111/dom.14419

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：2001 / 2003

页数：3

共 8 条

[1] A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci [J].

Bradfield, Jonathan P. ;

Qu, Hui-Qi ;

Wang, Kai ;

Zhang, Haitao ;

Sleiman, Patrick M. ;

Kim, Cecilia E. ;

Mentch, Frank D. ;

Qiu, Haijun ;

Glessner, Joseph T. ;

Thomas, Kelly A. ;

Frackelton, Edward C. ;

Chiavacci, Rosetta M. ;

Imielinski, Marcin ;

Monos, Dimitri S. ;

Pandey, Rahul ;

Bakay, Marina ;

Grant, Struan F. A. ;

Polychronakos, Constantin ;

Hakonarson, Hakon .

PLOS GENETICS, 2011, 7 (09)

[2] PRSice-2: Polygenic Risk Score software for biobank-scale data [J].

Choi, Shing Wan ;

O'Reilly, Paul F. .

GIGASCIENCE, 2019, 8 (07)

[3] Analysis of polygenic risk score usage and performance in diverse human populations [J].

Duncan, L. ;

Shen, H. ;

Gelaye, B. ;

Meijsen, J. ;

Ressler, K. ;

Feldman, M. ;

Peterson, R. ;

Domingue, B. .

NATURE COMMUNICATIONS, 2019, 10 (1)

[4] Towards clinical utility of polygenic risk scores [J].

Lambert, Samuel A. ;

Abraham, Gad ;

Inouye, Michael .

HUMAN MOLECULAR GENETICS, 2019, 28 (R2) :R133-R142

[5] Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score [J].

Onengut-Gumuscu, Suna ;

Chen, Wei-Min ;

Robertson, Catherine C. ;

Bonnie, Jessica K. ;

Farber, Emily ;

Zhu, Zhennan ;

Oksenberg, Jorge R. ;

Brant, Steven R. ;

Bridges, S. Louis, Jr. ;

Edberg, Jeffrey C. ;

Kimberly, Robert P. ;

Gregersen, Peter K. ;

Rewers, Marian J. ;

Steck, Andrea K. ;

Black, Mary H. ;

Dabelea, Dana ;

Pihoker, Catherine ;

Atkinson, Mark A. ;

Wagenknecht, Lynne E. ;

Divers, Jasmin ;

Bell, Ronny A. ;

Erlich, Henry A. ;

Concannon, Patrick ;

Rich, Stephen S. .

DIABETES CARE, 2019, 42 (03) :406-415

[6] Association of DLL1 with type 1 diabetes in patients characterized by low polygenic risk score [J].

Qu, Jingchun ;

Qu, Hui-Qi ;

Brad, Jonathan P. ;

Glessner, Joseph T. ;

Chang, Xiao ;

Tian, Lifeng ;

March, Michael E. ;

Roizen, Jeffrey D. ;

Sleiman, Patrick M. ;

Hakonarson, Hakon .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2021, 114

[7] Interaction of diabetes genetic risk and successful lifestyle modification in the Diabetes Prevention Programme [J].

Raghavan, Sridharan ;

Jablonski, Kathleen ;

Delahanty, Linda M. ;

Maruthur, Nisa M. ;

Leong, Aaron ;

Franks, Paul W. ;

Knowler, William C. ;

Florez, Jose C. ;

Dabelea, Dana .

DIABETES OBESITY & METABOLISM, 2021, 23 (04) :1030-1040

[8] Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis [J].

Sharp, Seth A. ;

Rich, Stephen S. ;

Wood, Andrew R. ;

Jones, Samuel E. ;

Beaumont, Robin N. ;

Harrison, James W. ;

Schneider, Darius A. ;

Locke, Jonathan M. ;

Tyrrell, Jess ;

Weedon, Michael N. ;

Hagopian, William A. ;

Oram, Richard A. .

DIABETES CARE, 2019, 42 (02) :200-207

← 1 →