COVID-19 and the small intestine

被引：3
作者：
Bakharev, Sergei D. [1 ]
Baulo, Elena, V [1 ]
Bykova, Svetlana, V [1 ]
Dbar, Saria R. [1 ]
Parfenov, Asfold, I [1 ]
机构：
[1] Loginov Moscow Clin Sci Ctr, Moscow, Russia
来源：
TERAPEVTICHESKII ARKHIV | 2021年 / 93卷 / 03期
关键词：
COVID-19; small intestine; angiotensin converting enzyme-2; enterocyte; oral-fecal route of infection; enteritis; colitis; probiotics; enteral/parenteral nutrition; ACUTE RESPIRATORY SYNDROME; SYNDROME-ASSOCIATED CORONAVIRUS; TISSUE DISTRIBUTION; SARS CORONAVIRUS; INFECTION; ACE2; RECEPTOR; DISEASE; PATHOGENESIS; COV;
D O I：
10.26442/00403660.2021.03.200662
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The SARS-CoV-2 virus enters the body through the angiotensin-converting enzyme 2 (ACE-2), which is the entry point of the virus into the cell. The most dense fabric of ACE-2 is the lungs. The small intestine also contains large amounts of ACE-2 in the enterocyte membrane and is often involved in this process. Intestinal symptoms can appear at different stages of the disease. The review describes the mechanisms of interaction of SARS-CoV-2 with enterocytes, the fecal-oral route of infection, diagnosis and treatment of COVID-19 with intestinal symptoms.
引用
收藏
页码：343 / 347
页数：5
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[1]   Coronavirus Disease 2019: A Gastroenterologist's Perspective in May 2020 [J].
Ahmed, Monjur .
GASTROENTEROLOGY RESEARCH, 2020, 13 (03) :89-95
[2]   Clinical Characteristics of COVID-19 Patients With Gastrointestinal Symptoms: An Analysis of Seven Patients in China [J].
Ai, Jin-Wei ;
Zi, Hao ;
Wang, Yong ;
Huang, Qiao ;
Wang, Na ;
Li, Lu-Yao ;
Pei, Bin ;
Ji, Jianguang ;
Zeng, Xian-Tao .
FRONTIERS IN MEDICINE, 2020, 7
[3]  
[Anonymous], 2020, N Engl J Med, V382, P1708, DOI DOI 10.1056/NEJMOA2002032
[4]   Tissue-Specific Amino Acid Transporter Partners ACE2 and Collectrin Differentially Interact With Hartnup Mutations [J].
Camargo, Simone M. R. ;
Singer, Dustin ;
Makrides, Victoria ;
Huggel, Katja ;
Pos, Klaas M. ;
Wagner, Carsten A. ;
Kuba, Keiji ;
Danilczyk, Ursula ;
Skovby, Flemming ;
Kleta, Robert ;
Penninger, Josef M. ;
Verrey, Francois .
GASTROENTEROLOGY, 2009, 136 (03) :872-882
[5]  
Cao B, 2020, NEW ENGL J MED, V382, P1787, DOI [10.1056/NEJMoa2001282, 10.1056/NEJMc2008043]
[6]   COVID-19 Disease With Positive Fecal and Negative Pharyngeal and Sputum Viral Tests [J].
Chen, Lijuan ;
Lou, Jianghua ;
Bai, Yan ;
Wang, Meiyun .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2020, 115 (05) :790-790
[7]   Structure analysis of the receptor binding of 2019-nCoV [J].
Chen, Yun ;
Guo, Yao ;
Pan, Yihang ;
Zhao, Zhizhuang Joe .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 525 (01) :135-140
[8]   Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China [J].
Chiu, SS ;
Chan, KH ;
Chu, KW ;
Kwan, SW ;
Guan, Y ;
Poon, LLM ;
Peiris, JSM .
CLINICAL INFECTIOUS DISEASES, 2005, 40 (12) :1721-1729
[9]   Diarrhea During COVID-19 Infection: Pathogenesis, Epidemiology, Prevention, and Management [J].
D'Amico, Ferdinando ;
Baumgart, Daniel C. ;
Danese, Silvio ;
Peyrin-Biroulet, Laurent .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2020, 18 (08) :1663-1672
[10]   Angiotensin-converting enzyme II in the heart and the kidney [J].
Danilczyk, U ;
Penninger, JM .
CIRCULATION RESEARCH, 2006, 98 (04) :463-471
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