Rapid preparation of pyranoquinolines using microwave dielectric heating in combination with fractional product distillation

被引：33
作者：
Razzaq, Tahseen
Kappe, C. Oliver
机构：
[1] Karl Franzens Univ Graz, CDLMC, A-8010 Graz, Austria
[2] Karl Franzens Univ Graz, Inst Chem, A-8010 Graz, Austria
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 14期
关键词：
heterocycles; cyclocondensation; microwave irradiation; distillation;
D O I：
10.1016/j.tetlet.2007.02.052
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
4-Hydroxy-6-methyl-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione was prepared by microwave-assisted cyclocondensation of N-methylaniline with 2 equiv of diethyl malonate. Key to the success of the synthesis was the use of open vessel controlled microwave heating technology, allowing the simultaneous removal of the formed ethanol from the reaction mixture by fractional distillation. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2513 / 2517
页数：5
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