Post-translational modification of p53 in tumorigenesis

被引：1027
作者：
Bode, AM [1 ]
Dong, ZG [1 ]
机构：
[1] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA
来源：
NATURE REVIEWS CANCER | 2004年 / 4卷 / 10期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrc1455
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Interest in the tumour suppressor p53 has generated much information regarding the complexity of its function and regulation in carcinogenesis. However, gaps still exist in our knowledge regarding the role of p53 post-translational modifications in carcinogenesis and cancer prevention. A thorough understanding of p53 will be extremely useful in the development of new strategies for treating and preventing cancer, including restoration of p53 function and selective killing of tumours with mutant TP53.
引用
收藏
页码：793 / 805
页数：13
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