Two-Component Approach Toward a Fully Substituted N-Fused Pyrrole Ring

被引：92

作者：

Chernyak, Dmitri ^{[1
]}

Skontos, Cathy ^{[1
]}

Gevorgyan, Vladimir ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 14期

基金：

美国国家卫生研究院;

关键词：

CATALYZED CYCLOISOMERIZATION; EFFICIENT SYNTHESIS; CONTAINING HETEROCYCLES; EXPEDITIOUS SYNTHESIS; TOPOISOMERASE-I; LAMELLARIN-D; INDOLIZINES; DERIVATIVES; CYCLIZATION;

D O I：

10.1021/ol1011949

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient two-component palladium-catalyzed arylation/cyclization cascade approach toward a variety of N-fused pyrroloheterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with propargylic esters or ethers followed by the 5-endo-dig cyclization leading to highly functionalized pyrroloheterocycles in good to excellent yield.

引用

收藏

页码：3242 / 3245

页数：4

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