17 alpha-hydroxyprogesterone caproate vehicle, castor oil, enhances the contractile effect of oxytocin in human myometrium in pregnancy

被引:24
作者
O'Sullivan, Michael D. [1 ]
Hehir, Mark P. [1 ]
O'Brien, Yvonne M. [1 ]
Morrison, John J. [1 ]
机构
[1] Natl Univ Ireland Galway, Inst Clin Sci, Dept Obstet & Gynecol, Galway Univ Hosp, Galway, Ireland
关键词
myometrium; preterm; progesterone; RECURRENT PRETERM DELIVERY; PREVENTION;
D O I
10.1016/j.ajog.2010.03.023
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: The possibility exists that the vehicle for 17-alpha-hydroxyprogesterone caproate, castor oil, exerts an effect on human uterine contractility. The aim of this study was to evaluate its effects on contractility of myometrial preparations that were obtained during pregnancy. STUDY DESIGN: Myometrial strips were suspended under isometric conditions. Contractility was induced with oxytocin. Strips were incubated in castor oil or physiologic salt solution and suspended for a further oxytocin challenge. Contractile integrals were compared between both groups. RESULTS: Strips that were exposed to castor oil demonstrated increased contractile activity that was elicited by oxytocin (mean contractility value, 165.53% +/- 17.03%; n = 8; P = .004), compared with control strips (mean contractility value, 72.57% +/- 7.48%; n = 8; P = .003). There was a significant increase in contractile activity of the castor oil-exposed strips, compared with those that were exposed to physiologic salt solution (n = 8; P < .001). CONCLUSION: Exposure of human myometrial preparations to castor oil results in enhanced oxytocin-induced contractility.
引用
收藏
页码:453.e1 / 453.e4
页数:4
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