Helicobacter pylori infection:: CagA-specific antibodies are associated with clinical outcome, but not with HLA-class II polymorphisms of the host

被引：6
|
作者：
Kunstmann, E [1 ]
Hardt, C
Crabtree, JE
Suerbaum, S
Epplen, JT
机构：
[1] Ruhr Univ Bochum, Dept Human Genet, D-44780 Bochum, Germany
[2] Hannover Med Sch, Dept Human Genet, Hannover, Germany
[3] St James Hosp, Leeds, W Yorkshire, England
[4] Univ Wurzburg, Inst Hyg & Microbiol, Wurzburg, Germany
来源：
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2003年 / 292卷 / 7-8期
关键词：
Helicobacter pylori; CagA; HLA-DRB1; TCRBV; host factors; gene polymorphism;
D O I：
10.1078/1438-4221-00237
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In order to investigate the interrelation between immunogenetic host and bacterial factors the T-cell receptor (TCR) polymorphism TCRBV6S1 AM, HLA-DRB1 alleles and cagA status was analyzed in 380 unrelated German individuals. H. pylori infection with cagA-positive bacterial strains was significantly associated with peptic ulcer disease in the German cohort. Patients homozygous for the non-functional TCRBV6S1B allele and presenting with peptic ulcer disease showed no CagA-specific antibodies in the majority of cases. There was no association between HLA-DRB1 alleles and the CagA status of infected individuals, although certain alleles show significant association to the infection status in different populations.
引用
收藏
页码：537 / 540
页数：4
相关论文
共 50 条
  • [21] Host epithelial interactions with Helicobacter pylori:: A role for disrupted gastric barrier function in the clinical outcome of infection?
    Buret, AG
    Fedwick, JP
    Flynn, AN
    CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2005, 19 (09) : 543 - 552
  • [22] Production of donor specific HLA class II antibodies is associated with cardiac graft vasculopathy
    不详
    INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 2005, 32 (04) : 261 - 261
  • [23] Desmoglein 3-specific antibodies generated in an HLA-class II-transgenic mouse model of pemphigus vulgaris are pathogenic
    Eming, R.
    Feliciani, C.
    Eubel, V.
    Podstawa, E.
    Mueller, R.
    Sonderstrup, G.
    Hertl, M.
    EXPERIMENTAL DERMATOLOGY, 2008, 17 (03) : 253 - 253
  • [24] Human desmocollin 3-specific IgG antibodies are pathogenic in a humanized HLA-class II transgenic mouse model of pemphigus
    Hudemann, C.
    Maglie, R.
    Beckert, B.
    Didona, D.
    Schmitt, T.
    Tikkanen, R.
    Hashimoto, T.
    Waschke, J.
    Hertl, M.
    Eming, R.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2021, 141 (10) : S150 - S150
  • [25] Polymorphisms in HLA Class II Genes Are Associated With Susceptibility to Staphylococcus aureus Infection in a White Population
    DeLorenze, Gerald N.
    Nelson, Charlotte L.
    Scott, William K.
    Allen, Andrew S.
    Ray, G. Thomas
    Tsai, Ai-Lin
    Quesenberry, Charles P., Jr.
    Fowler, Vance G., Jr.
    JOURNAL OF INFECTIOUS DISEASES, 2016, 213 (05): : 816 - 823
  • [26] MYOSITIS-SPECIFIC ANTIBODIES ARE ASSOCIATED WITH HLA CLASS-II ALLELES IN JAPANESE PATIENTS
    HIRAKATA, M
    SUWA, A
    NAKAMURA, K
    MIMORI, T
    AKIZUKI, M
    TAKEDA, Y
    HARDIN, JA
    ARTHRITIS AND RHEUMATISM, 1995, 38 (09): : 1008 - 1008
  • [27] Early acute humoral transplant rejection after living-donor kidney transplantation associated with Angiotensin II type 1-receptor antibodies and donor-specific HLA-class II antibodies
    Everding, A. Schulze
    Kuwertz-Broeking, E.
    Kelsch, R.
    Sibrowski, W.
    Broecker, V.
    Dragun, D.
    Konrad, M.
    PEDIATRIC NEPHROLOGY, 2009, 24 (04) : 913 - 913
  • [28] Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection
    Rad, R
    Dossumbekova, A
    Neu, B
    Lang, R
    Bauer, S
    Saur, D
    Gerhard, M
    Prinz, C
    GUT, 2004, 53 (08) : 1082 - 1089
  • [29] Association of H pylori cagA and vacA genotypes and IL-8 gene polymorphisms with clinical outcome of infection in Iranian patients with gastrointestinal diseases
    Eskandar Kamali-Sarvestani
    Abdulah Bazargani
    Malihe Masoudian
    Kamran Lankarani
    Ali-Reza Taghavi
    Mehdi Saberifiroozi
    World Journal of Gastroenterology, 2006, (32) : 5205 - 5210
  • [30] Association of H pylori cagA and vacA genotypes and IL-8 gene polymorphisms with clinical outcome of infection in Iranian patients with gastrointestinal diseases
    Kamali-Sarvestani, Eskandar
    Bazargani, Abdulah
    Masoudian, Malihe
    Lankarani, Kamran
    Taghavi, Ali-Reza
    Saberifiroozi, Mehdi
    WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (32) : 5205 - 5210
12345