Speckle interferometry applied to pharmacodynamic studies: evaluation of parasite motility

被引：35

作者：

Pomarico, JA

Di Rocco, HO

Alvarez, L

Lanusse, C

Mottier, L

Saumell, C

Arizaga, R

Rabal, H

Trivi, M

机构：

[1] UNCPBA, IFAS, Fac Ciencias Exactas, Tandil, Argentina

[2] UNCPBA, Fac Ciencias Vet, Tandil, Argentina

[3] Consejo Nacl Invest Cient & Tecn, CIC, Ctr Invest Opt, RA-1900 La Plata, Argentina

[4] UNLP, UID Optimo, Dept Fisicomatemat, Fac Ingn, RA-1900 La Plata, Argentina

来源：

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | 2004年 / 33卷 / 08期

关键词：

parasites; pharmacodynamics; speckle;

D O I：

10.1007/s00249-004-0413-4

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The work reported here describes the application of the optical technique known as dynamic speckle interferometry to evaluate the motility of nematode parasites exposed to different anthelmintic drugs. This technique, a well proven too] for assessing the time evolution of different phenomena, is here successfully used to quantify parasite motility in pharmacodynamic assays. The characterization of the pharmacological properties of anthelmintic drugs is critical to optimize their use in parasite control. Besides, the evaluation of nematode motility is a relevant indicator of the pharmacodynamic effect of anthelmintic drugs. The application of this approach to study the motility of Haemonchus contortus (used as a model of nematode parasites) larvae exposed to different drugs is presented, showing its usefulness.

引用

页码：694 / 699

页数：6

共 18 条

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