Antioxidant effect of caffeic acid phenethyl ester in experimentally induced periodontitis

被引：12

作者：

Otan Ozden, Feyza ^{[1
]}

Lutfioglu, Muge ^{[1
]}

Demir, Esra ^{[2
]}

Bilgici, Birsen ^{[3
]}

机构：

[1] Ondokuz Mayis Univ, Sch Dent, Dept Periodontol, TR-55139 Kurupelit, Samsun, Turkey

[2] Biruni Univ, Sch Dent, Dept Periodontol, Istanbul, Turkey

[3] Ondokuz Mayis Univ, Sch Med, Dept Biochem, Samsun, Turkey

来源：

CLINICAL ORAL INVESTIGATIONS | 2021年 / 25卷 / 08期

关键词：

Caffeic acid phenethyl ester; Experimental periodontitis; Total antioxidant status; Total oxidant status;

D O I：

10.1007/s00784-021-03805-y

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objectives The aim of the present study was to evaluate the antioxidant effect of systemically administered caffeic acid phenethyl ester (CAPE) in periodontitis. Materials and methods Forty rats were randomly divided into four groups: control, lipopolysaccharide-induced experimental periodontitis (LPS), CAPE 5: LPS+5 mu mol/kg/day CAPE, and CAPE 10: LPS+10 mu mol/kg/day CAPE. Following lipopolysaccharide-induced experimental periodontitis, CAPE was administered intraperitoneally for 28 days. Gingival and serumal total antioxidant status (TAS) and total oxidant status (TOS) were analyzed by enzyme-linked immunosorbent assay (ELISA). Results Gingival tissue TAS was significantly higher with CAPE application compared with the LPS group and was highest in the CAPE 10 group (p<0.05). Gingival tissue TOS was highest in the LPS group, and both of the CAPE dosages decreased the gingival tissue TOS, with the highest decrease in the CAPE 10 group (p<0.05). The differences were not significant for serumal TAS or TOS levels (p>0.05). Conclusions The effect of CAPE on increased TAS and decreased TOS levels in inflamed gingival tissue indicates the antioxidant therapeutic potential of CAPE in periodontitis.

引用

页码：4959 / 4966

页数：8

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