Bis(acridinylthiourea)platinum(II) Complexes: Synthesis, DNA affinity, and biological activity in ghoblastoma cells

被引：25
作者：
Augustus, TM
Anderson, J
Hess, SM
Bierbach, U [1 ]
机构：
[1] Wake Forest Univ, Dept Chem, Winston Salem, NC 27109 USA
[2] Wake Forest Univ, Sch Med, Dept Radiat Oncol, Winston Salem, NC 27157 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 05期
关键词：
D O I：
10.1016/S0960-894X(02)01078-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The preparation of two novel bis(acridine)platinum(II) complexes is reported. The 4+ charged conjugates associate strongly with double-stranded native DNA (K-i > 10(6)), possibly through bisintercalation. A cell viability assay was used to demonstrate that both compounds are capable of mediating cytotoxicity at micromolar concentrations in SNB19 brain tumor cells. (C) 2003 Elsevier Science Ltd. All rights reserved.
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页码：855 / 858
页数：4
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