Pharmacokinetic interaction study of combining imatinib with dasatinib in rats by UPLC-MS/MS
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作者:
Zhou, Yunfang
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Wenzhou Med Univ, Peoples Hosp Lishui City, Lab Clin Pharm, Lishui, Peoples R ChinaWenzhou Med Univ, Funct Expt Teaching Ctr, Wenzhou, Peoples R China
Zhou, Yunfang
[2
]
Wang, Shuanghu
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Wenzhou Med Univ, Peoples Hosp Lishui City, Lab Clin Pharm, Lishui, Peoples R ChinaWenzhou Med Univ, Funct Expt Teaching Ctr, Wenzhou, Peoples R China
Wang, Shuanghu
[2
]
Ding, Ting
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Wenzhou Med Univ, Peoples Hosp Lishui City, Lab Clin Pharm, Lishui, Peoples R ChinaWenzhou Med Univ, Funct Expt Teaching Ctr, Wenzhou, Peoples R China
Ding, Ting
[2
]
Wu, Mingdong
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Wenzhou Med Univ, Peoples Hosp Lishui City, Lab Clin Pharm, Lishui, Peoples R ChinaWenzhou Med Univ, Funct Expt Teaching Ctr, Wenzhou, Peoples R China
Wu, Mingdong
[2
]
Geng, Peiwu
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Wenzhou Med Univ, Peoples Hosp Lishui City, Lab Clin Pharm, Lishui, Peoples R ChinaWenzhou Med Univ, Funct Expt Teaching Ctr, Wenzhou, Peoples R China
Geng, Peiwu
[2
]
Zhang, Qingwei
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Shanghai Inst Pharmaceut Ind, Shanghai, Peoples R ChinaWenzhou Med Univ, Funct Expt Teaching Ctr, Wenzhou, Peoples R China
Zhang, Qingwei
[3
]
Ma, Jianshe
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Wenzhou Med Univ, Funct Expt Teaching Ctr, Wenzhou, Peoples R ChinaWenzhou Med Univ, Funct Expt Teaching Ctr, Wenzhou, Peoples R China
Ma, Jianshe
[1
]
机构:
[1] Wenzhou Med Univ, Funct Expt Teaching Ctr, Wenzhou, Peoples R China
[2] Wenzhou Med Univ, Peoples Hosp Lishui City, Lab Clin Pharm, Lishui, Peoples R China
[3] Shanghai Inst Pharmaceut Ind, Shanghai, Peoples R China
This study examined whether oral administration of dasatinib to the rats with imatinib led to any pharmacokinetic interactions. Twenty-four rats were divided randomly into three groups, imatinib group (imatinib 25mg/kg, n=8), dasatinib group (dasatinib 15mg/kg, n=8) and co-administration group (dasatinib 15mg/kg and imatinib 25mg/kg, n=8). The concentration of imatinib and dasatinib in rat plasma was determined by a sensitive and simple UPLC-MS/MS method. There was statistical pharmacokinetics difference for imatinib in the imatinib group and co-administration group, when co-oral administration imatinib with dasatinib, MRT(0-t) increased (p<0.01). There was statistical pharmacokinetics difference for dasatinib in the dasatinib group and co-administration group, when co-oral administration dasatinib with imatinib, C-max and AUC increased (p<0.01), CL and V decreased (p<0.01). These data indicate dasatinib could slightly influence the pharmacokinetic profile of imatinib in rats, and imatinib could influence the pharmacokinetic profile of dasatinib in rats, which might cause drug-drug interactions when using imatinib with dasatinib.