Possible roles of human (pro)renin receptor suggested by recent clinical and experimental findings

被引：23

作者：

Ichihara, Atsuhiro ^{[1
]}

Sakoda, Mariyo ^{[2
]}

Kurauchi-Mito, Asako ^{[2
]}

Narita, Tatsuya ^{[2
]}

Kinouchi, Kenichiro ^{[2
]}

Murohashi-Bokuda, Kanako ^{[2
]}

Itoh, Hiroshi ^{[2
]}

机构：

[1] Keio Univ, Sch Med, Dept Endocrinol & Antiaging Med, Shinjuku Ku, Tokyo 1608582, Japan

[2] Keio Univ, Sch Med, Dept Internal Med, Tokyo 1608582, Japan

来源：

HYPERTENSION RESEARCH | 2010年 / 33卷 / 03期

关键词：

angiotensin; ATP6ap2; handle region peptide; prorenin; vacuolar H+-ATPase; PRO RENIN RECEPTOR; RENIN/PRORENIN RECEPTOR; BLOOD-PRESSURE; NONPROTEOLYTIC ACTIVATION; SIGNAL-TRANSDUCTION; HANDLE-REGION; PRORENIN; PEPTIDE; BINDING; RATS;

D O I：

10.1038/hr.2009.214

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Numerous in vitro and in vivo animal studies using the (pro) renin receptor (P) RR blocker handle region peptide have suggested an important role of (P)RR in the pathogenesis of end-stage organ damage in patients with diabetes and hypertension. In addition, a limited number of clinical studies have suggested an association between (P) RR gene polymorphisms and blood pressure levels and between (P)RR mRNA levels and angiotensin-converting enzyme mRNA levels in human arteries. However, recent studies have shown that the (P)RR is divided into its soluble form and a residual hydrophobic part, which includes ATPase 6 associated protein 2, within cells. Therefore, the (P)RR may have a more complex function than previously thought. In addition, the physiological roles of the (P)RR remain undetermined, because the construction of (P)RR null mice has not been successful. As a next step for research in this area, a method for determining the soluble (P)RR levels in plasma and urine and the construction of tissue-specific (P)RR-knockout mice are needed to elucidate the roles of the (P)RR in physiology and pathophysiology. Hypertension Research (2010) 33, 177-180; doi:10.1038/hr.2009.214; published online 18 December 2009

引用

页码：177 / 180

页数：4

共 35 条

[1] The (Pro) Renin Receptor Site-Specific and Functional Linkage to the Vacuolar H+-ATPase in the Kidney [J].

Advani, Andrew ;

Kelly, Darren J. ;

Cox, Alison J. ;

White, Kathryn E. ;

Advani, Suzanne L. ;

Thai, Kerri ;

Connelly, Kim A. ;

Yuen, Darren ;

Trogadis, Judy ;

Herzenberg, Andrew M. ;

Kuliszewski, Michael A. ;

Leong-Poi, Howard ;

Gilbert, Richard E. .

HYPERTENSION, 2009, 54 (02) :261-U129

[2] Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor [J].

Batenburg, Wendy W. ;

Krop, Manne ;

Garrelds, Ingrid M. ;

de Vries, Rene ;

de Bruin, Rene J. A. ;

Burckle, Celine A. ;

Muller, Dominik N. ;

Bader, Michael ;

Nguyen, Genevieve ;

Danser, A. H. Jan .

JOURNAL OF HYPERTENSION, 2007, 25 (12) :2441-2453

[3] Soluble Form of the (Pro) Renin Receptor Generated by Intracellular Cleavage by Furin Is Secreted in Plasma [J].

Cousin, Christelle ;

Bracquart, Diane ;

Contrepas, Aurelie ;

Corvol, Pierre ;

Muller, Laurent ;

Nguyen, Genevieve .

HYPERTENSION, 2009, 53 (06) :1077-1082

[4] The putative (pro)renin receptor blocker HRP fails to prevent (pro)renin signaling [J].

Feldt, Sandra ;

Maschke, Ulrike ;

Dechend, Ralf ;

Luft, Friedrich C. ;

Muller, Dominik N. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 19 (04) :743-748

[5] Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release [J].

He, Ming ;

Zhang, Lin ;

Shao, Ying ;

Wang, Xiaofang ;

Huang, Yu ;

Yao, Tai ;

Lu, Limin .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2009, 606 (1-3) :155-161

[6] Gene expression of (pro)renin receptor is upregulated in hearts and kidneys of rats with congestive heart failure [J].

Hirose, Takuo ;

Mori, Nobuyoshi ;

Totsune, Kazuhito ;

Morimoto, Ryo ;

Maejima, Takahiro ;

Kawamura, Takuya ;

Metoki, Hirohito ;

Asayama, Kei ;

Kikuya, Masahiro ;

Ohkubo, Takayoshi ;

Kohzuki, Masahiro ;

Takahashi, Kazuhiro ;

Imai, Yutaka .

PEPTIDES, 2009, 30 (12) :2316-2322

[7] Association of (Pro)renin Receptor Gene Polymorphism With Blood Pressure in Japanese Men: The Ohasama Study [J].

Hirose, Takuo ;

Hashimoto, Masahiro ;

Totsune, Kazuhito ;

Metoki, Hirohito ;

Asayama, Kei ;

Kikuya, Masahiro ;

Sugimoto, Ken ;

Katsuya, Tomohiro ;

Ohkubo, Takayoshi ;

Hashimoto, Junichiro ;

Rakugi, Hiromi ;

Takahashi, Kazuhiro ;

Imai, Yutaka .

AMERICAN JOURNAL OF HYPERTENSION, 2009, 22 (03) :294-299

[8] Renin-stimulated TGF-β1 expression is regulated by a mitogen-activated protein kinase in mesangial cells [J].

Huang, Y. ;

Noble, N. A. ;

Zhang, J. ;

Xu, C. ;

Border, W. A. .

KIDNEY INTERNATIONAL, 2007, 72 (01) :45-52

[9] Renin increases mesangial cell transforming growth factor-β1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms [J].

Huang, Y ;

Wongamorntham, S ;

Kasting, J ;

McQuillan, D ;

Owens, RT ;

Yu, L ;

Noble, NA ;

Border, W .

KIDNEY INTERNATIONAL, 2006, 69 (01) :105-113

[10] Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension [J].

Ichihara, A ;

Kaneshiro, Y ;

Takemitsu, T ;

Sakoda, M ;

Suzuki, F ;

Nakagawa, T ;

Nishiyama, A ;

Inagami, T ;

Hayashi, M .

HYPERTENSION, 2006, 47 (05) :894-900

← 1 2 3 4 →