Role of Fks1p and Matrix Glucan in Candida albicans Biofilm Resistance to an Echinocandin, Pyrimidine, and Polyene

被引：149
作者：
Nett, Jeniel E. [1 ,3 ]
Crawford, Kyler [1 ]
Marchillo, Karen [1 ]
Andes, David R. [1 ,2 ]
机构：
[1] Univ Wisconsin, Dept Med, Madison, WI 53792 USA
[2] Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53792 USA
[3] Univ Wisconsin, Dept Cellular & Mol Biol, Madison, WI 53792 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 08期
基金：
美国国家卫生研究院;
关键词：
IN-VITRO; FLUCONAZOLE RESISTANCE; ANTIFUNGAL AGENTS; DRUG-RESISTANCE; EFFLUX PUMPS; IDENTIFICATION; GENE;
D O I：
10.1128/AAC.00227-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Candida infections frequently involve drug-resistant biofilm growth on device surfaces. Glucan synthase gene FKS1 has been linked to triazole resistance in Candida biofilms. We tested the impact of FKS1 modulation on susceptibility to additional antifungal classes. Reduction of FKS1 expression rendered biofilms more susceptible to amphotericin B, anidulafungin, and flucytosine. Increased resistance to anidulafungin and amphotericin B was observed for biofilms overexpressing FKS1. These findings suggest that Candida biofilm glucan sequestration is a multidrug resistance mechanism.
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收藏
页码：3505 / 3508
页数：4
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