Parental smoking and cessation during pregnancy and the risk of childhood asthma

被引:59
作者
Harju, Maijakaisa [1 ]
Keski-Nisula, Leea [1 ,2 ,3 ]
Georgiadis, Leena [1 ]
Heinonen, Seppo [4 ,5 ]
机构
[1] Kuopio Univ Hosp, Dept Obstet & Gynecol, POB 100, FI-70029 Kuopio, Finland
[2] Univ Eastern Finland, Fac Hlth Sci, Kuopio, Finland
[3] Natl Inst Hlth & Welf THL, Dept Environm Hlth, Kuopio, Finland
[4] Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland
[5] Univ Cent Hosp, Helsinki, Finland
关键词
Smoking; Pregnancy; Childhood; Asthma; Maternal; Paternal; Parental; ADVERSE BIRTH OUTCOMES; EXPOSURE; PREVALENCE; WEIGHT; TRENDS; WOMEN;
D O I
10.1186/s12889-016-3029-6
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: To evaluate the association between maternal and paternal smoking during pregnancy, and asthma among offspring. Methods: We conducted a hospital-based birth retrospective observational birth cohort study in a University-based Obstetrics and Gynecology Department, Kuopio University Hospital, Finland. 39 306 women, delivering between 1989 and 2006, were linked to the national register for asthma reimbursement for their offspring (2641 asthmatics). Pregnancy factors were recorded during pregnancy. Results: The risk of asthma was significantly elevated if both parents smoked (aOR 3.7; 95 % Cl 3.2-4.4) and it remained high in only paternal smoking families (aOR 2.9; 95 % Cl 2.5-3.3) as well as only maternal smoking families (aOR 1.7; 95 % Cl 1.2-2.2). Paternal cessation of smoking during pregnancy seemed to reduce the risk of asthma regardless of maternal smoking (aOR 0.3-0.4). Conclusions: Parental smoking, and especially paternal smoking, was significantly associated with the risk of asthma in offspring and paternal cessation of smoking during pregnancy was associated with a decreased risk of childhood asthma regardless of maternal smoking. The results indicate that both parents should be encouraged to quit smoking during pregnancy, since it is a relatively easy and cheap way to reduce the risk of asthma in offspring.
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页数:7
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