miR-204-5p suppresses cell proliferation by inhibiting IGFBP5 in papillary thyroid carcinoma

被引：110

作者：

Liu, Lianyong ^{[1
]}

Wang, Jingnan ^{[1
]}

Li, Xiangqi ^{[1
]}

Ma, Junhua ^{[1
]}

Shi, Chao ^{[1
]}

Zhu, Hongling ^{[1
]}

Xi, Qian ^{[1
]}

Zhang, Jichen ^{[1
]}

Zhao, Xuemei ^{[1
]}

Gu, Mingjun ^{[1
]}

机构：

[1] Shanghai Pudong Gongli Hosp, Dept Endocrine, Shanghai 200135, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2015年 / 457卷 / 04期

关键词：

miR-204-5p; IGFBP5; Papillary thyroid carcinoma; Proliferation; FACTOR-BINDING PROTEIN-5; BREAST-CANCER; COLORECTAL-CANCER; DIFFERENTIAL EXPRESSION; HUMAN OSTEOSARCOMA; TUMOR-SUPPRESSOR; GASTRIC-CANCER; GROWTH; INVASION; IDENTIFICATION;

D O I：

10.1016/j.bbrc.2015.01.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

microRNAs (miRNAs) are frequently dysregulated in human malignancies. It was recently shown that miR-204-5p is downregulated in papillary thyroid carcinoma (PTC); however, the functional significance of this observation is not known. This study investigated the role of miR-204-5p in PTC. Overexpressing miR-204-5p suppressed PTC cell proliferation and induced cell cycle arrest and apoptosis. The results of a luciferase reporter assay showed that miR-204-5p can directly bind to the 3' untranslated region (UTR) of insulin-like growth factor-binding protein 5 (IGFBP5) mRNA, and IGFBP5 overexpression partially reversed the growth-inhibitory effects of miR-204-5p. These results indicate that miR-204-5p acts as a tumor suppressor in PTC by regulating IGFBP5 expression and that miR-204-5p can potentially serve as an antitumorigenic agent in the treatment of PTC. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：621 / 626

页数：6

共 35 条

[1] Genetic Screen Identifies Insulin-like Growth Factor Binding Protein 5 as a Modulator of Tamoxifen Resistance in Breast Cancer [J].

Ahn, Bo Young ;

Elwi, Adam N. ;

Lee, Byoungchun ;

Trinh, Diane L. N. ;

Klimowicz, Alexander C. ;

Yau, Annie ;

Chan, Jennifer A. ;

Magliocco, Anthony ;

Kim, Sung-Woo .

CANCER RESEARCH, 2010, 70 (08) :3013-3019

[2] Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer [J].

Akkiprik, Mustafa ;

Feng, Yumei ;

Wang, Huamin ;

Chen, Kexin ;

Hu, Limei ;

Sahin, Aysegul ;

Krishnamurthy, Savitri ;

Ozer, Ayse ;

Hao, Xishan ;

Zhang, Wei .

BREAST CANCER RESEARCH, 2008, 10 (04)

[3]

[Anonymous], ONCOGENE

[4]

[Anonymous], ONCOGENE

[5] A TrkB-STAT3-miR-204-5p regulatory circuitry controls proliferation and invasion of endometrial carcinoma cells [J].

Bao, Wei ;

Wang, Hui-Hui ;

Tian, Fu-Ju ;

He, Xiao-Ying ;

Qiu, Mei-Ting ;

Wang, Jing-Yun ;

Zhang, Hui-Juan ;

Wang, Li-Hua ;

Wan, Xiao-Ping .

MOLECULAR CANCER, 2013, 12

[6] Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis [J].

Beattie, J ;

Allan, GJ ;

Lochrie, JD ;

Flint, DJ .

BIOCHEMICAL JOURNAL, 2006, 395 :1-19

[7] Insulin-like growth factor-binding protein-5 inhibits the growth of human breast cancer cells in vitro and in vivo [J].

Butt, AJ ;

Dickson, KA ;

McDougall, F ;

Baxter, RC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (32) :29676-29685

[8]

Chang H., 2014, Gut Liver

[9] Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA [J].

Ding, Jie ;

Huang, Shenglin ;

Wu, Shunquan ;

Zhao, Yingjun ;

Liang, Linhui ;

Yan, Mingxia ;

Ge, Chao ;

Yao, Jian ;

Chen, Taoyang ;

Wan, Dafang ;

Wang, Hongyang ;

Gu, Jianren ;

Yao, Ming ;

Li, Jinjun ;

Tu, Hong ;

He, Xianghuo .

NATURE CELL BIOLOGY, 2010, 12 (04) :390-U208

[10] Rising Thyroid Cancer Incidence in the United States by Demographic and Tumor Characteristics, 1980-2005 [J].

Enewold, Lindsey ;

Zhu, Kangmin ;

Ron, Elaine ;

Marrogi, Aizen J. ;

Stojadinovic, Alexander ;

Peoples, George E. ;

Devesa, Susan S. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (03) :784-791

← 1 2 3 4 →